Reference - Detail
| RRC ID | 45726 |
|---|---|
| Author | Edwards TJ, Hammarlund M. |
| Title | Syndecan promotes axon regeneration by stabilizing growth cone migration. |
| Journal | Cell Rep |
| Abstract |
Growth cones facilitate the repair of nervous system damage by providing the driving force for axon regeneration. Using single-neuron laser axotomy and in vivo time-lapse imaging, we show that syndecan, a heparan sulfate (HS) proteoglycan, is required for growth cone function during axon regeneration in C. elegans. In the absence of syndecan, regenerating growth cones form but are unstable and collapse, decreasing the effective growth rate and impeding regrowth to target cells. We provide evidence that syndecan has two distinct functions during axon regeneration: (1) a canonical function in axon guidance that requires expression outside the nervous system and depends on HS chains and (2) an intrinsic function in growth cone stabilization that is mediated by the syndecan core protein, independently of HS. Thus, syndecan is a regulator of a critical choke point in nervous system repair. |
| Volume | 8(1) |
| Pages | 272-83 |
| Published | 2014-7-10 |
| DOI | 10.1016/j.celrep.2014.06.008 |
| PII | S2211-1247(14)00476-8 |
| PMID | 25001284 |
| PMC | PMC4127196 |
| MeSH | Animals Caenorhabditis elegans / metabolism* Caenorhabditis elegans / physiology Growth Cones / metabolism* Growth Cones / physiology Nerve Regeneration* Syndecans / genetics Syndecans / metabolism* |
| IF | 8.109 |
| Times Cited | 24 |
| WOS Category | CELL BIOLOGY |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 4 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| C.elegans | tm734 tm3006 tm472 |