論文 - 詳細
| RRC ID | 45908 |
|---|---|
| 著者 | Zugasti O, Bose N, Squiban B, Belougne J, Kurz CL, Schroeder FC, Pujol N, Ewbank JJ. |
| タイトル | Activation of a G protein-coupled receptor by its endogenous ligand triggers the innate immune response of Caenorhabditis elegans. |
| ジャーナル | Nat Immunol |
| Abstract |
Immune defenses are triggered by microbe-associated molecular patterns or as a result of damage to host cells. The elicitors of immune responses in the nematode Caenorhabditis elegans are unclear. Using a genome-wide RNA-mediated interference (RNAi) screen, we identified the G protein-coupled receptor (GPCR) DCAR-1 as being required for the response to fungal infection and wounding. DCAR-1 acted in the epidermis to regulate the expression of antimicrobial peptides via a conserved p38 mitogen-activated protein kinase pathway. Through targeted metabolomics analysis we identified the tyrosine derivative 4-hydroxyphenyllactic acid (HPLA) as an endogenous ligand. Our findings reveal DCAR-1 and its cognate ligand HPLA to be triggers of the epidermal innate immune response in C. elegans and highlight the ancient role of GPCRs in host defense. |
| 巻・号 | 15(9) |
| ページ | 833-8 |
| 公開日 | 2014-9-1 |
| DOI | 10.1038/ni.2957 |
| PII | ni.2957 |
| PMID | 25086774 |
| PMC | PMC4139443 |
| MeSH | Animals Caenorhabditis elegans / immunology* Caenorhabditis elegans Proteins / immunology* Epidermis / immunology* Immunity, Innate / immunology* Ligands MAP Kinase Signaling System / immunology Mycoses / immunology* Phenylpropionates / immunology* RNA Interference Receptors, G-Protein-Coupled / immunology* Wounds and Injuries / immunology* |
| IF | 20.479 |
| 引用数 | 48 |
| WOS 分野 | IMMUNOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 3 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 3.0 |
| リソース情報 | |
| 線虫 | tm2484 tm3036 tm2487 |