RRC ID 45986
著者 Hertel P, Daniel J, Stegehake D, Vaupel H, Kailayangiri S, Gruel C, Woltersdorf C, Liebau E.
タイトル The ubiquitin-fold modifier 1 (Ufm1) cascade of Caenorhabditis elegans.
ジャーナル J Biol Chem
Abstract Ufm1 (ubiquitin-fold modifier 1) is the most recently identified member of the ubiquitin-like protein family. We characterized the Ufm1 cascade of the model organism Caenorhabditis elegans in terms of function and analyzed interactions of the involved proteins in vitro and in vivo. Furthermore, we investigated the phenotypes of the deletion mutants uba5(ok3364) (activating enzyme of Ufm1) and ufc1(tm4888) (conjugating enzyme of Ufm1). The viable deletion mutants showed a decrease in reproduction, development, life span, and a reduced survival under heavy metal stress. However, an increased survival rate under pathogenic, oxidative, heat, and endoplasmic reticulum stress was observed. We propose that the Ufm1 cascade negatively regulates the IRE1-mediated unfolded protein response.
巻・号 288(15)
ページ 10661-71
公開日 2013-4-12
DOI 10.1074/jbc.M113.458000
PII S0021-9258(20)67288-X
PMID 23449979
PMC PMC3624446
MeSH Animals Caenorhabditis elegans / genetics Caenorhabditis elegans / metabolism* Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism* Gene Deletion Heat-Shock Response / physiology Longevity / physiology Oxidative Stress / physiology Reproduction / physiology Unfolded Protein Response / physiology
IF 4.238
引用数 23
WOS 分野 BIOCHEMISTRY & MOLECULAR BIOLOGY
リソース情報
線虫 tm4888