RRC ID 46056
著者 Dierking K, Polanowska J, Omi S, Engelmann I, Gut M, Lembo F, Ewbank JJ, Pujol N.
タイトル Unusual regulation of a STAT protein by an SLC6 family transporter in C. elegans epidermal innate immunity.
ジャーナル Cell Host Microbe
Abstract The cuticle and epidermis of Caenorhabditis elegans provide the first line of defense against invading pathogens. Upon invasion by the fungal pathogen Drechmeria coniospora, C. elegans responds by upregulating the expression of antimicrobial peptides (AMPs) in the epidermis via activation of at least two pathways, a neuroendocrine TGF-β pathway and a p38 MAPK pathway. Here, we identify the sodium-neurotransmitter symporter SNF-12, a member of the solute carrier family (SLC6), as being essential for both these immune signaling pathways. We also identify the STAT transcription factor-like protein STA-2 as a direct physical interactor of SNF-12 and show that the two proteins function together to regulate AMP gene expression in the epidermis. Both SNF-12 and STA-2 act cell autonomously and specifically in the epidermis to govern the transcriptional response to fungal infection. These findings reveal an unorthodox mode of regulation for a STAT factor and highlight the molecular plasticity of innate immune signaling.
巻・号 9(5)
ページ 425-35
公開日 2011-5-19
DOI 10.1016/j.chom.2011.04.011
PII S1931-3128(11)00133-8
PMID 21575913
MeSH Animals Antimicrobial Cationic Peptides / biosynthesis Caenorhabditis elegans / genetics* Caenorhabditis elegans / immunology* Caenorhabditis elegans Proteins / metabolism* Epidermis / immunology GABA Plasma Membrane Transport Proteins / metabolism* Gene Expression Regulation* Hypocreales / immunology Immunity, Innate* Models, Biological Protein Binding Protein Interaction Mapping STAT Transcription Factors / metabolism*
IF 15.923
引用数 46
WOS 分野 PARASITOLOGY MICROBIOLOGY VIROLOGY
リソース情報
線虫 tm2261 tm692