| RRC ID |
46096
|
| Author |
Goehring NW, Trong PK, Bois JS, Chowdhury D, Nicola EM, Hyman AA, Grill SW.
|
| Title |
Polarization of PAR proteins by advective triggering of a pattern-forming system.
|
| Journal |
Science
|
| Abstract |
In the Caenorhabditis elegans zygote, a conserved network of partitioning-defective (PAR) polarity proteins segregates into an anterior and a posterior domain, facilitated by flows of the cortical actomyosin meshwork. The physical mechanisms by which stable asymmetric PAR distributions arise from transient cortical flows remain unclear. We present evidence that PAR polarity arises from coupling of advective transport by the flowing cell cortex to a multistable PAR reaction-diffusion system. By inducing transient PAR segregation, advection serves as a mechanical trigger for the formation of a PAR pattern within an otherwise stably unpolarized system. We suggest that passive advective transport in an active and flowing material may be a general mechanism for mechanochemical pattern formation in developmental systems.
|
| Volume |
334(6059)
|
| Pages |
1137-41
|
| Published |
2011-11-25
|
| DOI |
10.1126/science.1208619
|
| PII |
science.1208619
|
| PMID |
22021673
|
| MeSH |
Animals
Caenorhabditis elegans / embryology*
Caenorhabditis elegans / metabolism
Caenorhabditis elegans Proteins / genetics
Caenorhabditis elegans Proteins / metabolism*
Cell Polarity*
Cytoplasm / metabolism
Diffusion
Embryo, Nonmammalian / metabolism
Embryo, Nonmammalian / physiology*
Embryonic Development
Protein Serine-Threonine Kinases
Protein Transport
|
| IF |
41.846
|
| Times Cited |
145
|
|
WOS Category
|
CELL BIOLOGY
|
| Resource |
| C.elegans |
tm1425 |
