論文 - 詳細
| RRC ID | 46300 |
|---|---|
| 著者 | Cohen E, Yemini E, Schafer W, Feitelson DG, Treinin M. |
| タイトル | Locomotion analysis identifies roles of mechanosensory neurons in governing locomotion dynamics of C. elegans. |
| ジャーナル | J Exp Biol |
| Abstract |
The simple and well-characterized nervous system of C. elegans facilitates the analysis of mechanisms controlling behavior. Locomotion is a major behavioral output governed by multiple external and internal signals. Here, we examined the roles of low- and high-threshold mechanosensors in locomotion, using high-resolution and detailed analysis of locomotion and its dynamics. This analysis revealed a new role for touch receptor neurons in suppressing an intrinsic direction bias of locomotion. We also examined the response to noxious mechanical stimuli, which was found to involve several locomotion properties and to last several minutes. Effects on different locomotion properties have different half-lives and depend on different, partly overlapping sets of sensory neurons. PVD and FLP, high-threshold mechanosensors, play a major role in some of these responses. Overall, our results demonstrate the power of detailed, prolonged and high-resolution analysis of locomotion and locomotion dynamics in enabling better understanding of gene and neuron function. |
| 巻・号 | 215(Pt 20) |
| ページ | 3639-48 |
| 公開日 | 2012-10-15 |
| DOI | 10.1242/jeb.075416 |
| PII | jeb.075416 |
| PMID | 22811252 |
| MeSH | Animals Behavior, Animal / physiology Caenorhabditis elegans / physiology* Locomotion Mechanotransduction, Cellular* Sensory Receptor Cells / physiology* |
| IF | 3.014 |
| 引用数 | 12 |
| WOS 分野 | BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 各媒体での言及数の合計 | 0 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm1552 |