Reference - Detail
| RRC ID | 46536 |
|---|---|
| Author | Xu M, Joo HJ, Paik YK. |
| Title | Novel functions of lipid-binding protein 5 in Caenorhabditis elegans fat metabolism. |
| Journal | J Biol Chem |
| Abstract |
The lipid-binding protein (LBP) family is conserved from Caenorhabditis elegans to mammals and essential for fatty acid homeostasis. RNAi-mediated knockdown of nine C. elegans lbp family members revealed that lbp-5 regulates fat accumulation. C. elegans LBP-5 bound directly to various fatty acids with varying affinities. lbp-5 expression in nhr-49(nr2041) worms was much lower than in N2 worms. Nhr-49 transcriptional activity also decreased with lbp-5 deletion, suggesting that they may work together as functional partners in fat metabolism. In support of this notion, LBP-5 translocated into nuclei, where it appeared to influence C. elegans NHR-49 target genes involved in energy metabolism. Interestingly, LBP-5 is required for stearic acid-induced transcription of NHR-49 target genes. Thus, this knowledge could help identify therapeutic targets to treat obesity and diseases associated with nematode-host interactions. |
| Volume | 286(32) |
| Pages | 28111-8 |
| Published | 2011-8-12 |
| DOI | 10.1074/jbc.M111.227165 |
| PII | S0021-9258(20)57528-5 |
| PMID | 21697096 |
| PMC | PMC3151056 |
| MeSH | Active Transport, Cell Nucleus / physiology Animals Caenorhabditis elegans / genetics Caenorhabditis elegans / metabolism* Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism* Carrier Proteins / genetics Carrier Proteins / metabolism* Cell Nucleus / genetics Cell Nucleus / metabolism* Energy Metabolism / physiology Fatty Acid-Binding Proteins / genetics Fatty Acid-Binding Proteins / metabolism* Lipid Metabolism / physiology* Protein Binding Receptors, Cytoplasmic and Nuclear / genetics Receptors, Cytoplasmic and Nuclear / metabolism Stearic Acids / metabolism* Transcription, Genetic / physiology* |
| IF | 4.238 |
| Times Cited | 9 |
| WOS Category | BIOCHEMISTRY & MOLECULAR BIOLOGY |
| Resource | |
| C.elegans | tm1618 |