Reference - Detail
| RRC ID | 4661 |
|---|---|
| Author | Pandey BD, Pandey K, Kaneko O, Yanagi T, Hirayama K. |
| Title | Relapse of visceral leishmaniasis after miltefosine treatment in a Nepalese patient. |
| Journal | Am J Trop Med Hyg |
| Abstract |
We report the first case of visceral leishmaniasis (VL) relapse in a healthy individual after complete miltefosine treatment. The patient attended hospital with a history of fever for 2 months, splenomegaly, hepatomegaly, and weight loss. The case was confirmed as VL by microscopical detection of Leishmania parasites in a bone marrow specimen and by a positive result for the immunochromatography-based test targeting the Leishmania donovani rK39 antibody. A polymerase chain reaction (PCR) specific for the Leishmania kinetoplast minicircle gene was positive, and subsequent sequencing of the PCR-amplified product confirmed that this case was a L. donovani infection. The patient was treated with miltefosine for 28 days, during which time the response was good, and the Leishman-Donovan body (LD body) was negative on discharge. Ten months later, however, this patient again developed high fever and splenomegaly, and LD bodies and rK39 antibody were positive, thus indicating a relapse of VL. The patient was subsequently treated with 1 mg/kg of amphotericin B for a total of 14 days and recovered completely. |
| Volume | 80(4) |
| Pages | 580-2 |
| Published | 2009-4-1 |
| PII | 80/4/580 |
| PMID | 19346379 |
| MeSH | Antiprotozoal Agents / therapeutic use* Humans Leishmaniasis, Visceral / drug therapy* Leishmaniasis, Visceral / epidemiology Leishmaniasis, Visceral / pathology* Male Nepal / epidemiology Phosphorylcholine / analogs & derivatives* Phosphorylcholine / therapeutic use Recurrence Treatment Failure Young Adult |
| IF | 2.126 |
| Times Cited | 47 |
| WOS Category | TROPICAL MEDICINE PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | Policy sources |
| Total number of mentions | 1 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Pathogenic microorganisms | Leishumania donovani |