論文 - 詳細
| RRC ID | 46763 |
|---|---|
| 著者 | Hudry B, Khadayate S, Miguel-Aliaga I. |
| タイトル | The sexual identity of adult intestinal stem cells controls organ size and plasticity. |
| ジャーナル | Nature |
| Abstract |
Sex differences in physiology and disease susceptibility are commonly attributed to developmental and/or hormonal factors, but there is increasing realization that cell-intrinsic mechanisms play important and persistent roles. Here we use the Drosophila melanogaster intestine to investigate the nature and importance of cellular sex in an adult somatic organ in vivo. We find that the adult intestinal epithelium is a cellular mosaic of different sex differentiation pathways, and displays extensive sex differences in expression of genes with roles in growth and metabolism. Cell-specific reversals of the sexual identity of adult intestinal stem cells uncovers the key role this identity has in controlling organ size, reproductive plasticity and response to genetically induced tumours. Unlike previous examples of sexually dimorphic somatic stem cell activity, the sex differences in intestinal stem cell behaviour arise from intrinsic mechanisms that control cell cycle duration and involve a new doublesex- and fruitless-independent branch of the sex differentiation pathway downstream of transformer. Together, our findings indicate that the plasticity of an adult somatic organ is reversibly controlled by its sexual identity, imparted by a new mechanism that may be active in more tissues than previously recognized. |
| 巻・号 | 530(7590) |
| ページ | 344-8 |
| 公開日 | 2016-2-18 |
| DOI | 10.1038/nature16953 |
| PII | nature16953 |
| PMID | 26887495 |
| PMC | PMC4800002 |
| MeSH | Adult Stem Cells / cytology* Animals Cell Cycle Cell Proliferation Cell Transformation, Neoplastic Dosage Compensation, Genetic Drosophila Proteins / metabolism Drosophila melanogaster / anatomy & histology* Drosophila melanogaster / cytology* Drosophila melanogaster / genetics Drosophila melanogaster / growth & development Female Intestines / cytology* Male Nuclear Proteins / metabolism Organ Size* RNA-Binding Proteins / metabolism Reproduction Ribonucleoproteins / metabolism Sex Characteristics* Sex Differentiation / genetics |
| IF | 42.779 |
| 引用数 | 61 |
| WOS 分野 | GENETICS & HEREDITY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 145 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | 16724-R2 |