| RRC ID |
46790
|
| Author |
Kubota T, Watase S, Sakai K, Fromont J, Gonoi T, Kobayashi J.
|
| Title |
Tyrokeradines G and H, new bromotyrosine alkaloids from an Okinawan Verongid sponge.
|
| Journal |
Bioorg Med Chem Lett
|
| Abstract |
Two new bromotyrosine alkaloids, tyrokeradines G (1) and H (2), have been isolated from an Okinawan marine sponge of the order Verongida. The structures of 1 and 2 were elucidated on the basis of spectroscopic data. Tyrokeradine G (1) is the first bromotyrosine alkaloid possessing a β-alanine unit, while tyrokeradine H (2) is a rare bromotyrosine alkaloid possessing a N-substituted pyridinium ring. Tyrokeradines G (1) and H (2) showed antifungal activity.
|
| Volume |
25(22)
|
| Pages |
5221-3
|
| Published |
2015-11-15
|
| DOI |
10.1016/j.bmcl.2015.09.061
|
| PII |
S0960-894X(15)30095-0
|
| PMID |
26459215
|
| MeSH |
Alkaloids / chemistry*
Alkaloids / isolation & purification*
Alkaloids / pharmacology
Animals
Antifungal Agents / chemistry*
Antifungal Agents / isolation & purification*
Antifungal Agents / pharmacology
Aspergillus niger / drug effects
Cryptococcus neoformans / drug effects
Porifera
Tyrosine / analogs & derivatives*
Tyrosine / chemistry
Tyrosine / isolation & purification
Tyrosine / pharmacology
|
| IF |
2.572
|
| Times Cited |
5
|
|
WOS Category
|
CHEMISTRY, MEDICINAL
CHEMISTRY, ORGANIC
|
| Resource |
| Pathogenic microorganisms |
NA |
