Reference - Detail
| RRC ID | 46790 |
|---|---|
| Author | Kubota T, Watase S, Sakai K, Fromont J, Gonoi T, Kobayashi J. |
| Title | Tyrokeradines G and H, new bromotyrosine alkaloids from an Okinawan Verongid sponge. |
| Journal | Bioorg Med Chem Lett |
| Abstract |
Two new bromotyrosine alkaloids, tyrokeradines G (1) and H (2), have been isolated from an Okinawan marine sponge of the order Verongida. The structures of 1 and 2 were elucidated on the basis of spectroscopic data. Tyrokeradine G (1) is the first bromotyrosine alkaloid possessing a β-alanine unit, while tyrokeradine H (2) is a rare bromotyrosine alkaloid possessing a N-substituted pyridinium ring. Tyrokeradines G (1) and H (2) showed antifungal activity. |
| Volume | 25(22) |
| Pages | 5221-3 |
| Published | 2015-11-15 |
| DOI | 10.1016/j.bmcl.2015.09.061 |
| PII | S0960-894X(15)30095-0 |
| PMID | 26459215 |
| MeSH | Alkaloids / chemistry* Alkaloids / isolation & purification* Alkaloids / pharmacology Animals Antifungal Agents / chemistry* Antifungal Agents / isolation & purification* Antifungal Agents / pharmacology Aspergillus niger / drug effects Cryptococcus neoformans / drug effects Porifera Tyrosine / analogs & derivatives* Tyrosine / chemistry Tyrosine / isolation & purification Tyrosine / pharmacology |
| IF | 2.572 |
| Times Cited | 5 |
| WOS Category | CHEMISTRY, MEDICINAL CHEMISTRY, ORGANIC |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 2 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Pathogenic microorganisms | NA |