| RRC ID |
46807
|
| 著者 |
Kogure Y, Nakamura F, Shinozaki-Ushiku A, Watanabe A, Kamei K, Yoshizato T, Nannya Y, Fukayama M, Kurokawa M.
|
| タイトル |
Pulmonary mucormycosis with embolism: two autopsied cases of acute myeloid leukemia.
|
| ジャーナル |
Int J Clin Exp Pathol
|
| Abstract |
Mucormycosis is an increasingly important cause of morbidity and mortality for patients with hematological malignancies. The diagnosis of mucormycosis usually requires mycological evidence through tissue biopsy or autopsy because the signs and symptoms are nonspecific and there are currently no biomarkers to identify the disease. We herein present two autopsied cases of acute myeloid leukemia with prolonged neutropenia who developed invasive mucormycosis accompanied by pulmonary artery embolism. Our cases were featured by unexplained fever and rapidly progressive dyspnea. Computed tomography scan detected nodular lesions or nonspecific consolidations in the lungs. Cultures, cytological study, and serum fungal markers consistently gave negative results. Autopsy revealed embolism of the pulmonary artery which consisted of fibrin clots by filamentous fungi. Genomic DNA was extracted from the paraffin-embedded clots and was applied to polymerase chain reaction amplification, leading to the diagnosis of infection by Rhizopus microsporus. We should carefully search for life-threatening pulmonary embolism when patients with hematological malignancies develop pulmonary mucormycosis.
|
| 巻・号 |
7(6)
|
| ページ |
3449-53
|
| 公開日 |
2014-1-1
|
| PMID |
25031775
|
| PMC |
PMC4097268
|
| MeSH |
Adult
Aged, 80 and over
Antineoplastic Agents / therapeutic use
Autopsy
Bone Marrow Transplantation
Humans
Immunocompromised Host*
Immunosuppressive Agents / therapeutic use
Leukemia, Myeloid, Acute / therapy*
Male
Mucormycosis / complications*
Mucormycosis / immunology
Mucormycosis / pathology
Pulmonary Embolism / etiology*
Pulmonary Embolism / pathology
|
| IF |
0.252
|
| 引用数 |
1
|
|
WOS 分野
|
ONCOLOGY
PATHOLOGY
|
| リソース情報 |
| 病原微生物 |
|
