Reference - Detail
| RRC ID | 46855 |
|---|---|
| Author | Kubota T, Ishiguro Y, Takahashi-Nakaguchi A, Fromont J, Gonoi T, Kobayashi J. |
| Title | Manzamenones L-N, new dimeric fatty-acid derivatives from an Okinawan marine sponge Plakortis sp. |
| Journal | Bioorg Med Chem Lett |
| Abstract |
Three new polyketides, manzamenones L-N (1-3), have been isolated from an Okinawan marine sponge of the genus Plakortis. The structures of 1-3 were elucidated on the basis of spectroscopic data. Manzamenones L-N (1-3) were new dimeric fatty-acid derivatives consisting of a tetrahydroindenone with three carboxy groups and two hexadecanyl chains. Manzamenones M (2) and N (3) showed antimicrobial activity against several bacteria and fungi. |
| Volume | 23(1) |
| Pages | 244-7 |
| Published | 2013-1-1 |
| DOI | 10.1016/j.bmcl.2012.10.109 |
| PII | S0960-894X(12)01411-4 |
| PMID | 23186727 |
| MeSH | Animals Anti-Infective Agents / chemistry* Anti-Infective Agents / isolation & purification Anti-Infective Agents / pharmacology Bacteria / drug effects Bone Marrow Cells / cytology Dendritic Cells / cytology Dendritic Cells / drug effects Dendritic Cells / metabolism Fatty Acids / chemistry* Fatty Acids / isolation & purification Fatty Acids / pharmacology Fungi / drug effects Indenes / chemistry* Indenes / isolation & purification Indenes / pharmacology Interleukin-12 / metabolism Interleukin-6 / metabolism Japan Magnetic Resonance Spectroscopy Mice Mice, Inbred C57BL Molecular Conformation Plakortis / chemistry* Polyketides / chemistry* Polyketides / isolation & purification Polyketides / pharmacology Tumor Necrosis Factor-alpha / metabolism |
| IF | 2.572 |
| Times Cited | 7 |
| WOS Category | CHEMISTRY, MEDICINAL CHEMISTRY, ORGANIC |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | Patent(IFI CLAIMS) |
| Total number of mentions | 1 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Pathogenic microorganisms | NA |