Reference - Detail
| RRC ID | 46858 |
|---|---|
| Author | Mochizuki K, Sawada A, Suemori S, Kawakami H, Niwa Y, Kondo Y, Ohkusu K, Yamada N, Ogura S, Yaguchi T, Nishimura K, Kishino S. |
| Title | Intraocular penetration of intravenous micafungin in inflamed human eyes. |
| Journal | Antimicrob Agents Chemother |
| Abstract |
Eight eyes of 7 patients with fungal disease received intravenous injections of 150 to 300 mg micafungin, and samples of blood, cornea, retina-choroid, aqueous humor, and vitreous humor were collected. The micafungin levels in all collected samples exceeded the MICs; however, the levels in the vitreous and aqueous humors were lower. Our findings suggest that intravenous micafungin should be given in combination with intravitreal antifungal agents after vitrectomy in severe cases of intraocular fungal diseases. |
| Volume | 57(8) |
| Pages | 4027-30 |
| Published | 2013-8-1 |
| DOI | 10.1128/AAC.02300-12 |
| PII | AAC.02300-12 |
| PMID | 23689706 |
| PMC | PMC3719741 |
| MeSH | Aged Aged, 80 and over Antifungal Agents / administration & dosage* Antifungal Agents / pharmacokinetics Aqueous Humor / metabolism Aspergillus / drug effects Aspergillus / isolation & purification Candida / drug effects Candida / isolation & purification Cornea / drug effects Cornea / microbiology* Echinocandins / administration & dosage* Echinocandins / pharmacokinetics Endophthalmitis / drug therapy* Endophthalmitis / microbiology Female Humans Injections, Intraocular / methods Lipopeptides / administration & dosage* Lipopeptides / pharmacokinetics Male Micafungin Vitrectomy / methods Vitreous Body / metabolism |
| IF | 4.904 |
| Times Cited | 18 |
| WOS Category | PHARMACOLOGY & PHARMACY MICROBIOLOGY |
| Resource | |
| Pathogenic microorganisms | |