RRC ID 46863
著者 Okubo Y, Wakayama M, Ohno H, Yamamoto S, Tochigi N, Tanabe K, Kaneko Y, Yamagoe S, Umeyama T, Shinozaki M, Nemoto T, Nakayama H, Sasai D, Ishiwatari T, Shimodaira K, Yamamoto Y, Kamei K, Miyazaki Y, Shibuya K.
タイトル Histopathological study of murine pulmonary cryptococcosis induced by Cryptococcus gattii and Cryptococcus neoformans.
ジャーナル Jpn J Infect Dis
Abstract Although Cryptococcus gattii can cause life-threatening complications, putative virulence factors of C. gattii remain controversial. Therefore, we conducted the present study to elucidate the virulence factors of the yeast and found that the mortality rate of mice infected with C. gattii R265 was significantly higher than that of those infected with C. gattii 5815; however, no difference was found in the mortality rates between mice infected with C. gattii R265 and Cryptococcus neoformans H99. In contrast, we found a significant difference in histopathological findings of the lungs between mice infected with C. gattii R265 and C. neoformans H99. The former showed alveolar expansion due to yeast proliferation with much lesser macrophage response, whereas the latter showed numerous nodules in the alveolar space consisting of macrophages and multinucleated giant cells. Furthermore, alveolar expansion was more enhanced in mice infected with C. gattii R265 than in those infected with C. gattii 5815. Our study confirmed that there is a different pathophysiology leading to death during C. gattii and C. neoformans infections. The result can provide two characteristics of C. gattii: one includes some mechanisms to escape from host recognition via macrophage and another includes a high performance of pulmonary structural alteration. These characteristics may be associated with the high virulence of C. gattii.
巻・号 66(3)
ページ 216-21
公開日 2013-1-1
DOI 10.7883/yoken.66.216
PII DN/JST.JSTAGE/yoken/66.216
PMID 23698482
MeSH Animals Cryptococcosis / parasitology Cryptococcosis / pathology* Cryptococcus gattii / pathogenicity* Cryptococcus neoformans / pathogenicity* Disease Models, Animal Female Histocytochemistry Lung / pathology* Lung Diseases, Parasitic / parasitology Lung Diseases, Parasitic / pathology* Mice Mice, Inbred C57BL Survival Analysis Virulence
IF 1.24
引用数 20
WOS 分野 INFECTIOUS DISEASES
リソース情報
病原微生物