RRC ID 46864
Author Takagi Y, Fukano H, Shimozato K, Tanaka R, Horii T, Kawamoto F, Kanbe T.
Title Genotypes of Candida albicans isolated from healthy individuals and their distribution in patients with oral candidiasis.
Journal J Infect Chemother
Abstract For the study of Candida albicans genotypes involved in development of candidiasis, Candida albicans isolates were collected from healthy volunteers and patients with oral candidiasis and genotyped on the basis of 25S rDNA and microsatellite polymorphisms. In the microsatellite analysis using two microsatellite markers (CDC3 and CAI), 63 healthy volunteer isolates were classified into 35 genotypes (allelic relations to CDC3 alleles 1:2/CAI alleles 1:2), among which genotypes II (115:119/23:23), III (115:123/18:27), and V (123:127/32:41) were found at frequencies of 12.7%, 7.9%, and 7.9%, respectively. In 68 oral candidiasis isolates classified into 39 genotypes, genotypes II and III were identified in 4.4% and 20.6% of the isolates, respectively. The frequency of genotype III was higher in the candidiasis isolates than in the healthy isolates (p < 0.05). These results suggest that genotype III C. albicans assigned by CDC3/CAI is related to the development of oral candidiasis.
Volume 19(6)
Pages 1072-9
Published 2013-12-1
DOI 10.1007/s10156-013-0626-5
PII S1341-321X(13)70009-6
PMID 23757030
MeSH Adult Aged Candida albicans / genetics* Candida albicans / isolation & purification Candidiasis, Oral / microbiology* Carrier State / microbiology* Case-Control Studies DNA, Fungal / genetics Female Genotype Humans Male
IF 1.722
Times Cited 3
Pathogenic microorganisms NA