RRC ID 46875
Author Gyotoku H, Izumikawa K, Ikeda H, Takazono T, Morinaga Y, Nakamura S, Imamura Y, Nishino T, Miyazaki T, Kakeya H, Yamamoto Y, Yanagihara K, Yasuoka A, Yaguchi T, Ohno H, Miyzaki Y, Kamei K, Kanda T, Kohno S.
Title A case of bronchial aspergillosis caused by Aspergillus udagawae and its mycological features.
Journal Med Mycol
Abstract Aspergillus udagawae and A. fumigatus share similar morphological features but they differ genetically. There is also an important clinical distinction as A. udagawae is less sensitive to amphotericin B than A. fumigatus. We encountered a rare case of bronchial infection due to A. udagawae that was successfully treated with voriconazole. An 82-year-old woman with diabetes mellitus complained of bloody sputum. Bronchoscopy revealed a white plugged region at the origin of the right bronchi B5. Cytological study revealed a clot composed of filamentous fungi and Aspergillus spp. was detected by culture. Molecular analysis revealed that the causative agent was A. udagawae, and voriconazole was used for the treatment. In comparison to A. fumigatus, the A. udagawae strain isolated in this case was less sensitive to amphotericin B, less virulent in immunosuppressed mice, and more sensitive to hydrogen peroxide, features that are almost identical to those of the previously reported isolates of the fungus. We should be aware of the emergence of new Aspergillus species that might pose a clinical threat.
Volume 50(6)
Pages 631-6
Published 2012-8-1
DOI 10.3109/13693786.2011.639036
PMID 22149972
MeSH Aged, 80 and over Animals Aspergillosis / drug therapy Aspergillosis / microbiology* Aspergillus / classification Aspergillus / drug effects Aspergillus / isolation & purification* Aspergillus / pathogenicity Bronchial Diseases / drug therapy Bronchial Diseases / microbiology* Bronchial Diseases / pathology Bronchoscopy / methods Diabetes Mellitus / pathology Female Humans Hydrogen Peroxide / pharmacology Immunocompromised Host Lung / microbiology Lung / pathology Mice Pyrimidines / therapeutic use Triazoles / therapeutic use Voriconazole
IF 2.822
Times Cited 15
Pathogenic microorganisms