RRC ID 46916
Author Hu Y, Zheng D, Takizawa K, Mikami Y, Dai L, Yazawa K, Fukushima K, Lu C, Xi L.
Title Systemic nocardiosis caused by Nocardia concava in China.
Journal Med Mycol
Abstract A 42-year-old man with polychondritis and a 2-year history of using low-dose prednisone and other immunosuppressive drugs was admitted to our hospital due to persistent high fever of 10 days duration. A strain of Nocardia was twice isolated from his blood and subsequently identified to be N. concava. The patient was initially treated with sulphadiazine sodium, vancomycin and imipenema for 7 days but the symptoms persisted. Consequently, the regimen was changed to sulphadiazine sodium, ciprofloxacin and amikacin sulfate based on the antibiotic susceptibility tests of the Nocardia isolate. The fever disappeared and the patient's condition improved after 10 days of this treatment to the extent that he was discharged. However, 7 days later, the patient's condition deteriorated and he died due to multiple organ failure. This is the first report of N. concava causing systemic nocardiosis in China.
Volume 49(6)
Pages 662-6
Published 2011-8-1
DOI 10.3109/13693786.2011.555849
PMID 21284569
MeSH Adult Anti-Bacterial Agents / administration & dosage Bacteremia / complications Bacteremia / diagnosis* Bacteremia / drug therapy Bacteremia / pathology* Bacterial Typing Techniques Blood / microbiology China DNA Gyrase / genetics DNA, Bacterial / chemistry DNA, Bacterial / genetics Fatal Outcome Histocytochemistry Humans Liver / pathology Lung / pathology Male Microbial Sensitivity Tests Molecular Sequence Data Multiple Organ Failure Nocardia / isolation & purification* Nocardia Infections / complications Nocardia Infections / diagnosis* Nocardia Infections / drug therapy Nocardia Infections / pathology* Phylogeny Radiography, Abdominal Radiography, Thoracic Sequence Analysis, DNA Tomography, X-Ray Computed
IF 2.822
Times Cited 10
Pathogenic microorganisms IFM 0354 IFM 0576 IFM 10912