RRC ID 46918
Author Kon Y, Kubota T, Shibazaki A, Gonoi T, Kobayashi J.
Title Ceratinadins A-C, new bromotyrosine alkaloids from an Okinawan marine sponge Pseudoceratina sp.
Journal Bioorg Med Chem Lett
Abstract Three new bromotyrosine alkaloids, ceratinadins A-C (1-3), were isolated from an Okinawan marine sponge Pseudoceratina sp. and the structures of 1-3 were elucidated on the basis of spectroscopic data. Ceratinadin A (1) was a novel bromotyrosine alkaloid possessing an N-imidazolyl-quinolinone moiety. Ceratinadins A (1) and B (2) showed antifungal activity.
Volume 20(15)
Pages 4569-72
Published 2010-8-1
DOI 10.1016/j.bmcl.2010.06.015
PII S0960-894X(10)00779-1
PMID 20584605
MeSH Alkaloids / chemistry* Alkaloids / isolation & purification Alkaloids / pharmacology Animals Antifungal Agents / chemistry* Antifungal Agents / isolation & purification Antifungal Agents / pharmacology Imidazoles / chemistry* Imidazoles / isolation & purification Imidazoles / pharmacology Magnetic Resonance Spectroscopy Molecular Conformation Porifera / chemistry* Quinolines / chemistry* Quinolines / isolation & purification Quinolines / pharmacology Tyrosine / analogs & derivatives* Tyrosine / chemistry
IF 2.572
Times Cited 28
Pathogenic microorganisms NA