論文 - 詳細
| RRC ID | 46920 |
|---|---|
| 著者 | Lee JH, Kim HL, Lee MH, Taguchi H, Hyon SH, Park JC. |
| タイトル | Antimicrobial effect of medical adhesive composed of aldehyded dextran and ε-Poly(L-Lysine). |
| ジャーナル | J Microbiol Biotechnol |
| Abstract |
Infection of surgical wounds is a severe problem. Conventional tissue reattachment methods have limits of incomplete sealing and high susceptibility to infection. Medical adhesives have several advantages over traditional tissue reattachment techniques, but still have drawbacks, such as the probability of infection, low adhesive strength, and high cytotoxicity. Recently, a new medical adhesive (new-adhesive) with high adhesive strength and low cytotoxicity, composed of aldehyded dextran and ε-poly(L-lysine), was developed. The antimicrobial activity of the new-adhesive was assayed using agar media and porcine skin. In the agar diffusion method, inoculated microorganisms that contacted the new-adhesive were inactivated, but this was not dependent on the amount of new-adhesive. Similar to the agar media results, the topical antimicrobial effect of new-adhesive was confirmed using a porcine skin antimicrobial assay, and the effect was not due to physical blocking based on comparison with the group whose wounds were wrapped. |
| 巻・号 | 21(11) |
| ページ | 1199-202 |
| 公開日 | 2011-11-1 |
| DOI | 10.4014/jmb.1105.05054 |
| PII | JMB021-11-15 |
| PMID | 22127133 |
| MeSH | Animals Anti-Infective Agents / pharmacology* Bacteria / drug effects Candida albicans / drug effects Dextrans / pharmacology* Microbial Sensitivity Tests / methods Microbial Viability / drug effects Polylysine / pharmacology* Skin / microbiology Swine Tissue Adhesives / pharmacology* |
| IF | 1.992 |
| 引用数 | 3 |
| WOS 分野 | BIOTECHNOLOGY & APPLIED MICROBIOLOGY MICROBIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 病原微生物 | |