Reference - Detail
| RRC ID | 46925 |
|---|---|
| Author | Nagayoshi M, Tada Y, West J, Ochiai E, Watanabe A, Toyotome T, Tanabe N, Takiguchi Y, Shigeta A, Yasuda T, Shibuya K, Kamei K, Tatsumi K. |
| Title | Inhalation of Stachybotrys chartarum evokes pulmonary arterial remodeling in mice, attenuated by Rho-kinase inhibitor. |
| Journal | Mycopathologia |
| Abstract |
Stachybotrys chartarum, a ubiquitous fungus in our environment, has been suspected of causing respiratory symptoms in humans, such as acute infant pulmonary hemorrhage and asthma. We previously established a mouse model in which repeated inhalation of Stachybotrys chartarum spores caused pulmonary hypertension. To further investigate the model, particularly in the pulmonary circulation, mice were intra-tracheally injected with spores, 18 times over 12 weeks. Severe muscularization was observed in the small- to medium-sized pulmonary arteries. Bronchoalveolar lavage fluid revealed an increase in eosinophils accompanied by high concentrations of Th2-associated cytokines, IL-4, IL-5, but not Th1-associated IFN-γ. The remodeling was temporary, resolving after cessation of spore inhalation. Chronic inhibition of the RhoA/Rho-kinase pathway by fasudil attenuated pulmonary arterial remodeling. These data suggest that Stachybotrys-mediated remodeling is caused by Th2-associated inflammation and can be resolved by Rho-kinase inhibition, either through direct effects on smooth muscle hypertrophy or through indirect effects on vascular inflammation. These data also show that extensive pulmonary vascular remodeling, often thought of as a fixed lesion, will spontaneously resolve in the absence of underlying molecular etiology. |
| Volume | 172(1) |
| Pages | 5-15 |
| Published | 2011-7-1 |
| DOI | 10.1007/s11046-011-9400-3 |
| PMID | 21505873 |
| MeSH | 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine / administration & dosage 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine / analogs & derivatives Animals Cytokines / metabolism Disease Models, Animal Lung / microbiology* Lung / pathology* Lung Diseases, Fungal / microbiology* Lung Diseases, Fungal / pathology* Male Mice Neovascularization, Pathologic* Protein Kinase Inhibitors / administration & dosage Rodent Diseases / microbiology Rodent Diseases / pathology Stachybotrys / pathogenicity* Th2 Cells / immunology rho-Associated Kinases / antagonists & inhibitors* |
| IF | 2.452 |
| Times Cited | 12 |
| WOS Category | MYCOLOGY |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | Policy sources |
| Total number of mentions | 1 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Pathogenic microorganisms | IFM 53637 |