| RRC ID |
46950
|
| 著者 |
Ogata R, Hagiwara E, Shiihara J, Ogura T, Takahashi H, Kamei K.
|
| タイトル |
[A case of lung scedosporiosis successfully treated with monitoring of plasma voriconazole concentration level].
|
| ジャーナル |
Nihon Kokyuki Gakkai Zasshi
|
| Abstract |
A 71-year-old man was referred because of fever and productive cough. His chest radiograph showed a large cavitary mass with an intracavitary mycetoma-like lesion in the left middle lung field. We undertook bronchoscopy and CT-guided biopsy, and both bronchial lavage fluid culture and CT-guided biopsy culture revealed Scedosporium apiospermum. On a diagnosis of lung scedosporiosis, he was treated with 200 mg/day voriconazole for 2 months, but his symptoms did not improve. Measurement of the plasma voriconazole level showed low plasma concentration levels (peak level: 2.15 microg/ml, trough level: 0.72 microg/ml). We then increased the voriconazole dosage from 200 mg/day to 400 mg/day. After that, his symptoms and chest radiograph findings improved immediately, accompanied by an elevated plasma voriconazole level (peak level: 5.13 microg/ml, trough level: 3.13 microg/ml). We believe that measurement of plasma voriconazole levels is useful to determine its dosage in lung scedosporiosis.
|
| 巻・号 |
49(5)
|
| ページ |
388-92
|
| 公開日 |
2011-5-1
|
| PMID |
21688649
|
| MeSH |
Aged
Antifungal Agents / administration & dosage*
Antifungal Agents / blood*
Humans
Lung Diseases, Fungal / drug therapy*
Male
Pyrimidines / administration & dosage*
Pyrimidines / blood*
Scedosporium*
Triazoles / administration & dosage*
Triazoles / blood*
Voriconazole
|
| リソース情報 |
| 病原微生物 |
|
