RRC ID 46953
Author Nishikata N, Nakamori K, Sueyoshi M, Takahashi H, Yuji H, Sano A.
Title [Evaluation of antifungal effects of a traditional medicine containing 17 components on Trichophyton verrucosum and Malassezia pachydermatis by microdilution].
Journal Med Mycol J
Abstract The minimum inhibitory concentration(MIC)of a traditional medicine containing 17 components against 9 strains of Trichophyton verrucosum and 13 strains of Malassezia pachydermatis was determined using a method recommended by the Clinical and Laboratory Standards Institute(CLSI). We also measured the MIC of each of the 17 components using the same method, and identified the main antifungal components.In order to evaluate MIC as a parameter of the antifungal effects using the microdilution method, we prepared 10% working solutions from 10% (w/v)medicines. The geometric mean MIC of the medicinal extract against T. verrucosum was 2.51%, and that against M. pachydermatis was 2.25%. The components that exhibited antifungal effects were Rheum palmatum, Glycyrrhiza uralensis, Magnolia obovata, Phellodendron amurense, and Geranium thunbergii.
Volume 52(3)
Pages 213-21
Published 2011-1-1
DOI 10.3314/mmj.52.213
PII JST.JSTAGE/mmj/52.213
PMID 21891983
MeSH Animals Drug Resistance, Fungal Drugs, Chinese Herbal / chemistry* Drugs, Chinese Herbal / pharmacology* Malassezia / drug effects* Microbial Sensitivity Tests / methods* Trichophyton / drug effects*
Pathogenic microorganisms IFM 5798 IFM 40205 IFM 40212 IFM 40214 IFM 54301 IFM 55518 IFM 56537 IFM 56813 IFM 57574 IFM 57575 IFM 58256 IFM 58543 IFM 58544 IFM 58793 IFM 58794 IFM 58795 IFM 58796 IFM 58797 IFM 58798 IFM 58799 IFM 58800 IFM 58801 IFM 58802