RRC ID 46970
著者 Oarada M, Igarashi M, Tsuzuki T, Kamei K, Hirasaka K, Nikawa T, Miyazawa T, Nakagawa K, Gonoi T.
タイトル Effects of a high-protein diet on host resistance to Paracoccidioides brasiliensis in mice.
ジャーナル Biosci Biotechnol Biochem
Abstract We investigated the effects of high protein intake on host resistance to Paracoccidioides brasiliensis. Two-d fasted mice were infected with P. brasiliensis and refed on diets with three different levels (54%, 20%, and 5%) of casein. The mice refed the 54% casein diet showed reduced antifungal activity in the spleen and liver as compared with the mice refed the 5% or the 20% casein diet. After infection, increases in spleen and liver mRNA levels of myeloperoxidase, cathepsin-G, and elastase-2 were more profound in the mice refed the 54% casein diet as compared with the mice refed the 5% or the 20% casein diet. Infected mice refed the 54% casein diet exhibited greater interferon (IFN)-gamma production in the spleen and liver and higher levels of thiobarbituric acid reactive substances (TBARSs) in the liver as compared with those refed the 5% casein diet. These results indicate that high protein intake impairs host resistance to P. brasiliensis.
巻・号 74(3)
ページ 620-6
公開日 2010-1-1
DOI 10.1271/bbb.90829
PII JST.JSTAGE/bbb/90829
PMID 20208341
MeSH Animals Caseins / immunology Cathepsin G / analysis Dietary Proteins / administration & dosage* Female Host-Pathogen Interactions / immunology* Interferon-gamma / metabolism Liver / enzymology Liver / immunology Mice Mice, Inbred BALB C Paracoccidioides / immunology* Paracoccidioidomycosis / immunology* Peroxidase / analysis Serine Endopeptidases / analysis Spleen / enzymology Spleen / immunology Thiobarbituric Acid Reactive Substances / metabolism
IF 1.516
引用数 5
WOS 分野 FOOD SCIENCE & TECHNOLOGY CHEMISTRY, APPLIED BIOTECHNOLOGY & APPLIED MICROBIOLOGY BIOCHEMISTRY & MOLECULAR BIOLOGY
リソース情報
病原微生物