RRC ID |
46970
|
著者 |
Oarada M, Igarashi M, Tsuzuki T, Kamei K, Hirasaka K, Nikawa T, Miyazawa T, Nakagawa K, Gonoi T.
|
タイトル |
Effects of a high-protein diet on host resistance to Paracoccidioides brasiliensis in mice.
|
ジャーナル |
Biosci Biotechnol Biochem
|
Abstract |
We investigated the effects of high protein intake on host resistance to Paracoccidioides brasiliensis. Two-d fasted mice were infected with P. brasiliensis and refed on diets with three different levels (54%, 20%, and 5%) of casein. The mice refed the 54% casein diet showed reduced antifungal activity in the spleen and liver as compared with the mice refed the 5% or the 20% casein diet. After infection, increases in spleen and liver mRNA levels of myeloperoxidase, cathepsin-G, and elastase-2 were more profound in the mice refed the 54% casein diet as compared with the mice refed the 5% or the 20% casein diet. Infected mice refed the 54% casein diet exhibited greater interferon (IFN)-gamma production in the spleen and liver and higher levels of thiobarbituric acid reactive substances (TBARSs) in the liver as compared with those refed the 5% casein diet. These results indicate that high protein intake impairs host resistance to P. brasiliensis.
|
巻・号 |
74(3)
|
ページ |
620-6
|
公開日 |
2010-1-1
|
DOI |
10.1271/bbb.90829
|
PII |
JST.JSTAGE/bbb/90829
|
PMID |
20208341
|
MeSH |
Animals
Caseins / immunology
Cathepsin G / analysis
Dietary Proteins / administration & dosage*
Female
Host-Pathogen Interactions / immunology*
Interferon-gamma / metabolism
Liver / enzymology
Liver / immunology
Mice
Mice, Inbred BALB C
Paracoccidioides / immunology*
Paracoccidioidomycosis / immunology*
Peroxidase / analysis
Serine Endopeptidases / analysis
Spleen / enzymology
Spleen / immunology
Thiobarbituric Acid Reactive Substances / metabolism
|
IF |
1.516
|
引用数 |
5
|
WOS 分野
|
FOOD SCIENCE & TECHNOLOGY
CHEMISTRY, APPLIED
BIOTECHNOLOGY & APPLIED MICROBIOLOGY
BIOCHEMISTRY & MOLECULAR BIOLOGY
|
リソース情報 |
病原微生物 |
|