Reference - Detail
| RRC ID | 46971 |
|---|---|
| Author | Ohji G, Kikuchi K, Inoue K, Imoto K, Yamamoto S, Hosokawa N, Kamei K, Iwata K. |
| Title | Progressive disseminated histoplasmosis in an immunocompetent patient as an underrecognized imported mycosis in Japan. |
| Journal | J Infect Chemother |
| Abstract |
Histoplasmosis caused by Histoplasma capsulatum is found worldwide. Japan is known to be non-endemic area. Progressive disseminated histoplasmosis (PDH) is a severe form of histoplasmosis. We report a case of PDH in a 54-year-old male who was not immunocompromised. His last travel history to an endemic region was 2 years before onset. He was diagnosed as histoplasmosis by 18S rRNA-PCR from serum and ascites and immunodiffusion test. We treated him with parental liposomal amphotericin B for 2 weeks then changed to oral itraconazole, which was continued for 6 months. Rigorous work up, including HIV status, lymphocyte counts, and adrenal function did not reveal any evidence of immunosuppression of the patient. Our case suggests that PDH can occur in immunocompetent patients as previously described, and must be included in the differential diagnoses if presentation is consistent. In addition, the skills of travel history taking are emphasized. |
| Volume | 16(6) |
| Pages | 443-5 |
| Published | 2010-12-1 |
| DOI | 10.1007/s10156-010-0073-5 |
| PII | S1341-321X(10)70569-9 |
| PMID | 20549287 |
| MeSH | Amphotericin B / therapeutic use Antifungal Agents / therapeutic use Histoplasma / genetics Histoplasma / isolation & purification* Histoplasmosis / diagnosis* Histoplasmosis / drug therapy Histoplasmosis / microbiology Humans Immunocompetence* Itraconazole / therapeutic use Japan Male Middle Aged Polymerase Chain Reaction / methods RNA, Ribosomal, 18S / genetics Travel* |
| IF | 1.722 |
| Times Cited | 1 |
| WOS Category | PHARMACOLOGY & PHARMACY INFECTIOUS DISEASES |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 2 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Pathogenic microorganisms | NA |