RRC ID 46983
Author Watanabe A, Matsumoto K, Igari H, Uesato M, Yoshida S, Nakamura Y, Morita K, Shibuya K, Matsubara H, Yoshino I, Kamei K.
Title Comparison between concentrations of amphotericin B in infected lung lesion and in uninfected lung tissue in a patient treated with liposomal amphotericin B (AmBisome).
Journal Int J Infect Dis
Abstract Generally, the primary lesion of a mold infection is in the airway, an extravascular site. Therefore, the antifungal drug concentration at the actual tissue lesion of a mold infection is as important as in the blood compartment. Although our antifungal armamentarium has expanded recently, polyenes are still often needed in clinical practice because of their potent fungicidal activity and the rarity of resistance. Nevertheless, the distribution of amphotericin B (AmB) in infected lung tissue has not yet been evaluated. Using high-performance liquid chromatography analysis, we determined the concentrations of AmB in plasma and infected and uninfected tissues of resected lung simultaneously, in a patient with pulmonary aspergillosis treated with liposomal amphotericin B (L-AmB). The AmB concentration in the infected lesion of the lung was approximately 5.2 times higher than that in plasma and 3.7 times higher than in uninfected lung tissue. L-AmB accumulated in the infected lesion of the lung at a higher concentration. Although our data are from only one patient, they may be useful in helping to develop better strategies for the use of L-AmB against pulmonary fungal infections.
Volume 14 Suppl 3
Pages e220-3
Published 2010-9-1
DOI 10.1016/j.ijid.2009.07.020
PII S1201-9712(09)00334-8
PMID 19959388
MeSH Amphotericin B / blood Amphotericin B / pharmacokinetics* Amphotericin B / therapeutic use Antifungal Agents / blood Antifungal Agents / pharmacokinetics* Antifungal Agents / therapeutic use Aspergillus niger* Humans Liposomes Lung / metabolism Lung / microbiology Male Middle Aged Pulmonary Aspergillosis / blood Pulmonary Aspergillosis / drug therapy* Pulmonary Aspergillosis / metabolism* Tissue Distribution
IF 3.202
Times Cited 12
Pathogenic microorganisms