RRC ID 47039
Author Liu XP, Fan SR, Bai FY, Li J, Liao QP.
Title Antifungal susceptibility and genotypes of Candida albicans strains from patients with vulvovaginal candidiasis.
Journal Mycoses
Abstract Studies of the genetic diversity of Candida albicans strains and the correlation between the antifungal susceptibility and gene diversity of C. albicans were carried out and the results were found to be inconsistent. To investigate antifungal susceptibility and genotypes of C. albicans strains from patients with vulvovaginal candidiasis (VVC), the genotypes of C. albicans in patients with VVC were studied using a recently developed polymerase chain reaction-single strand conformation polymorphism (PCR-SSCP) of CAI microsatellite method and antifungal susceptibility was tested using E-test methods. Twenty-six genotypes were identified from 89 strains of C. albicans isolated from patients with VVC. Candida albicans isolates were susceptible to amphotericin B, flucytosine, ketoconazole and fluconazole. The dominant genotypes (A, B, C, D) account for 69.7% (62/89) of C. albicans. The resistant rate of C. albicans genotype B to itraconazole (ITR) and that of C. albicans non-genotype B strains were 66.7% (14/21) and 4.4% (3/68) respectively at P < 0.05. We concluded that C. albicans genotype B from patients with VVC was more resistant to ITR.
Volume 52(1)
Pages 24-8
Published 2009-1-1
DOI 10.1111/j.1439-0507.2008.01539.x
PMID 18498300
MeSH Adult Antifungal Agents / pharmacology* Candida albicans / drug effects* Candida albicans / genetics* Candida albicans / isolation & purification Candidiasis, Vulvovaginal / microbiology* Cluster Analysis DNA, Fungal / genetics* Female Genetic Variation* Genotype Humans Microbial Sensitivity Tests Polymerase Chain Reaction / methods Polymorphism, Single-Stranded Conformational
IF 3.575
Times Cited 19
Pathogenic microorganisms