論文 - 詳細
| RRC ID | 47058 |
|---|---|
| 著者 | Fan SR, Bai FY, Liao QP, Liu ZH, Li J, Liu XP. |
| タイトル | Genotype distribution of Candida albicans strains associated with different conditions of vulvovaginal candidiasis, as revealed by microsatellite typing. |
| ジャーナル | Sex Transm Infect |
| Abstract |
OBJECTIVE:To compare genotypes of Candida albicans strains causing different conditions of vulvovaginal candidiasis (VVC) in Chinese women. METHODS:C albicans strains were isolated from the vaginas of patients with different conditions of VVC. The genotypes of the strains were investigated based on single-strand conformation polymorphisms (SSCP) of the PCR amplified microsatellite locus CAI. RESULTS:A total of 93 independent C albicans strains was isolated from patients with mild-to-moderate (n = 37) or severe (n = 56) VVC. Thirty of the patients enrolled suffered recurrent VVC. Twenty-six distinct genotypes tentatively designated as A to Z were identified from the 93 C albicans strains compared on the basis of their CAI SSCP patterns. The majority (72.0%) of the strains possessed genotypes A to D, which were similar in the CAI SSCP profiles and were designated as the dominant genotypes. The overall frequencies of the four dominant genotypes were 87.5% (49/56) and 48.6% (18/37; p<0.001) in the C albicans strains from patients with severe and mild-to-moderate VVC, respectively. The strains with the dominant genotypes occupied 83.3% (25/30) and 66.7% (42/63; p = 0.094) in the C albicans strains from patients with recurrent VVC and sporadic VVC, respectively. CONCLUSION:The frequency of C albicans strains with the dominant genotypes (A to D) from patients with severe VVC was significantly higher than that from patients with mild-to-moderate VVC, implying that the CAI genotype distribution of C albicans strains correlates with the severity of VVC. |
| 巻・号 | 84(2) |
| ページ | 103-6 |
| 公開日 | 2008-4-1 |
| DOI | 10.1136/sti.2007.025700 |
| PII | sti.2007.025700 |
| PMID | 17971371 |
| MeSH | Adult Candida albicans / genetics* Candidiasis, Vulvovaginal / genetics* Female Gene Frequency Genotype* Humans Microsatellite Repeats Middle Aged Polymorphism, Genetic / genetics Recurrence Vagina / microbiology* |
| IF | 3.396 |
| 引用数 | 24 |
| WOS 分野 | INFECTIOUS DISEASES |
| リソース情報 | |
| 病原微生物 | NA |