論文 - 詳細
| RRC ID | 47270 |
|---|---|
| 著者 | Turner HN, Armengol K, Patel AA, Himmel NJ, Sullivan L, Iyer SC, Bhattacharya S, Iyer EPR, Landry C, Galko MJ, Cox DN. |
| タイトル | The TRP Channels Pkd2, NompC, and Trpm Act in Cold-Sensing Neurons to Mediate Unique Aversive Behaviors to Noxious Cold in Drosophila. |
| ジャーナル | Curr Biol |
| Abstract |
The basic mechanisms underlying noxious cold perception are not well understood. We developed Drosophila assays for noxious cold responses. Larvae respond to near-freezing temperatures via a mutually exclusive set of singular behaviors-in particular, a full-body contraction (CT). Class III (CIII) multidendritic sensory neurons are specifically activated by cold and optogenetic activation of these neurons elicits CT. Blocking synaptic transmission in CIII neurons inhibits CT. Genetically, the transient receptor potential (TRP) channels Trpm, NompC, and Polycystic kidney disease 2 (Pkd2) are expressed in CIII neurons, where each is required for CT. Misexpression of Pkd2 is sufficient to confer cold responsiveness. The optogenetic activation level of multimodal CIII neurons determines behavioral output, and visualization of neuronal activity supports this conclusion. Coactivation of cold- and heat-responsive sensory neurons suggests that the cold-evoked response circuitry is dominant. Our Drosophila model will enable a sophisticated molecular genetic dissection of cold nociceptive genes and circuits. |
| 巻・号 | 26(23) |
| ページ | 3116-3128 |
| 公開日 | 2016-12-5 |
| DOI | 10.1016/j.cub.2016.09.038 |
| PII | S0960-9822(16)31122-8 |
| PMID | 27818173 |
| PMC | PMC5140760 |
| MeSH | Animals Cold Temperature* Drosophila / physiology* Drosophila Proteins / genetics Drosophila Proteins / metabolism* Gene Expression Regulation Larva / physiology Nociception / physiology Sensory Receptor Cells / physiology* Transient Receptor Potential Channels / physiology* |
| IF | 9.601 |
| 引用数 | 25 |
| WOS 分野 | BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY |
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 23 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
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