Reference - Detail
| RRC ID | 4732 |
|---|---|
| Author | Shuaibu MN, Pandey K, Wuyep PA, Yanagi T, Hirayama K, Ichinose A, Tanaka T, Kouno I. |
| Title | Castalagin from Anogeissus leiocarpus mediates the killing of Leishmania in vitro. |
| Journal | Parasitol Res |
| Abstract |
Stem barks of Anogeissus leiocarpus and Terminalia avicennoides widely used in Africa for treatment of some parasitic diseases were collected and made into methanolic extracts. The extracts were tested on four strains of promastigote forms of Leishmania in vitro. Solvent fractionation in aqueous, butanolic, and ethyl acetate layer indicated butanol and aqueous fractions to have a superior leishmanicidal activity. Chromatographic separation of the butanolic fraction on Sephadex LH-20 followed by nuclear magnetic resonance and correlation high-performance liquid chromatography revealed the presence of known hydrolyzable tannins and some related compounds-with castalagin as the major compound. The observed activity ranged from 62.5 to > or =150, 112.5 to > or =500, and 55 to >150 microg/ml for the crude methanolic extract, different solvent fractions, and the isolated compounds, respectively, on the four different Leishmania strains. |
| Volume | 103(6) |
| Pages | 1333-8 |
| Published | 2008-11-1 |
| DOI | 10.1007/s00436-008-1137-7 |
| PMID | 18690475 |
| MeSH | Animals Combretaceae / chemistry* Hydrolyzable Tannins / analysis Hydrolyzable Tannins / isolation & purification Hydrolyzable Tannins / pharmacology* Leishmania / classification Leishmania / drug effects* Medicine, African Traditional Parasitic Sensitivity Tests Plant Bark / chemistry* Plant Extracts / chemistry Plant Extracts / pharmacology Plant Stems / chemistry* Plants, Medicinal / chemistry |
| IF | 1.641 |
| Times Cited | 28 |
| WOS Category | PARASITOLOGY |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | Wikipedia |
| Total number of mentions | 9 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Pathogenic microorganisms | Leishmania aethiopica Leishmania amazonensis Leishmania donovani |