論文 - 詳細
| RRC ID | 47424 |
|---|---|
| 著者 | Yamagata N, Hiroi M, Kondo S, Abe A, Tanimoto H. |
| タイトル | Suppression of Dopamine Neurons Mediates Reward. |
| ジャーナル | PLoS Biol |
| Abstract |
Massive activation of dopamine neurons is critical for natural reward and drug abuse. In contrast, the significance of their spontaneous activity remains elusive. In Drosophila melanogaster, depolarization of the protocerebral anterior medial (PAM) cluster dopamine neurons en masse signals reward to the mushroom body (MB) and drives appetitive memory. Focusing on the functional heterogeneity of PAM cluster neurons, we identified that a single class of PAM neurons, PAM-γ3, mediates sugar reward by suppressing their own activity. PAM-γ3 is selectively required for appetitive olfactory learning, while activation of these neurons in turn induces aversive memory. Ongoing activity of PAM-γ3 gets suppressed upon sugar ingestion. Strikingly, transient inactivation of basal PAM-γ3 activity can substitute for reward and induces appetitive memory. Furthermore, we identified the satiety-signaling neuropeptide Allatostatin A (AstA) as a key mediator that conveys inhibitory input onto PAM-γ3. Our results suggest the significance of basal dopamine release in reward signaling and reveal a circuit mechanism for negative regulation. |
| 巻・号 | 14(12) |
| ページ | e1002586 |
| 公開日 | 2016-12-1 |
| DOI | 10.1371/journal.pbio.1002586 |
| PII | PBIOLOGY-D-16-01066 |
| PMID | 27997541 |
| PMC | PMC5172549 |
| MeSH | Animals Dopaminergic Neurons / metabolism Dopaminergic Neurons / physiology* Drosophila melanogaster Mesencephalon / cytology Mesencephalon / metabolism Mushroom Bodies / metabolism Peptides / physiology Reward* Signal Transduction |
| IF | 7.076 |
| 引用数 | 25 |
| WOS 分野 | BIOLOGY BIOCHEMISTRY & MOLECULAR BIOLOGY |
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 39 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
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