論文 - 詳細
| RRC ID | 47426 |
|---|---|
| 著者 | Iatsenko I, Kondo S, Mengin-Lecreulx D, Lemaitre B. |
| タイトル | PGRP-SD, an Extracellular Pattern-Recognition Receptor, Enhances Peptidoglycan-Mediated Activation of the Drosophila Imd Pathway. |
| ジャーナル | Immunity |
| Abstract |
Activation of the innate immune response in Metazoans is initiated through the recognition of microbes by host pattern-recognition receptors. In Drosophila, diaminopimelic acid (DAP)-containing peptidoglycan from Gram-negative bacteria is detected by the transmembrane receptor PGRP-LC and by the intracellular receptor PGRP-LE. Here, we show that PGRP-SD acted upstream of PGRP-LC as an extracellular receptor to enhance peptidoglycan-mediated activation of Imd signaling. Consistent with this, PGRP-SD mutants exhibited impaired activation of the Imd pathway and increased susceptibility to DAP-type bacteria. PGRP-SD enhanced the localization of peptidoglycans to the cell surface and hence promoted signaling. Moreover, PGRP-SD antagonized the action of PGRP-LB, an extracellular negative regulator, to fine-tune the intensity of the immune response. These data reveal that Drosophila PGRP-SD functions as an extracellular receptor similar to mammalian CD14 and demonstrate that, comparable to lipopolysaccharide sensing in mammals, Drosophila relies on both intra- and extracellular receptors for the detection of bacteria. |
| 巻・号 | 45(5) |
| ページ | 1013-1023 |
| 公開日 | 2016-11-15 |
| DOI | 10.1016/j.immuni.2016.10.029 |
| PII | S1074-7613(16)30440-X |
| PMID | 27851910 |
| MeSH | Animals Carrier Proteins / immunology* Disease Models, Animal Drosophila Proteins / immunology* Drosophila melanogaster / immunology* Gram-Negative Bacterial Infections / immunology* Immunity, Innate / immunology Myogenic Regulatory Factors / immunology* Peptidoglycan / immunology Polymerase Chain Reaction Receptors, Pattern Recognition / immunology Signal Transduction / immunology* |
| IF | 22.553 |
| 引用数 | 28 |
| WOS 分野 | IMMUNOLOGY |
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 9 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
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