論文 - 詳細
| RRC ID | 47429 |
|---|---|
| 著者 | Yoo SK, Pascoe HG, Pereira T, Kondo S, Jacinto A, Zhang X, Hariharan IK. |
| タイトル | Plexins function in epithelial repair in both Drosophila and zebrafish. |
| ジャーナル | Nat Commun |
| Abstract |
In most multicellular organisms, homeostasis is contingent upon maintaining epithelial integrity. When unanticipated insults breach epithelial barriers, dormant programmes of tissue repair are immediately activated. However, many of the mechanisms that repair damaged epithelia remain poorly characterized. Here we describe a role for Plexin A (PlexA), a protein with particularly well-characterized roles in axonal pathfinding, in the healing of damaged epithelia in Drosophila. Semaphorins, which are PlexA ligands, also regulate tissue repair. We show that Drosophila PlexA has GAP activity for the Rap1 GTPase, which is known to regulate the stability of adherens junctions. Our observations suggest that the inhibition of Rap1 activity by PlexA in damaged Drosophila epithelia allows epithelial remodelling, thus facilitating wound repair. We also demonstrate a role for Plexin A1, a zebrafish orthologue of Drosophila PlexA, in epithelial repair in zebrafish tail fins. Thus, plexins function in epithelial wound healing in diverse taxa. |
| 巻・号 | 7 |
| ページ | 12282 |
| 公開日 | 2016-7-25 |
| DOI | 10.1038/ncomms12282 |
| PII | ncomms12282 |
| PMID | 27452696 |
| PMC | PMC4962468 |
| MeSH | Actins / metabolism Adherens Junctions / metabolism Animal Fins / metabolism Animals Cell Adhesion Molecules / metabolism* Drosophila melanogaster / metabolism* Epithelial Cells / metabolism Epithelium / metabolism* Nerve Tissue Proteins / metabolism* RNA Interference Signal Transduction Wound Healing* Zebrafish / metabolism* |
| IF | 12.121 |
| 引用数 | 14 |
| WOS 分野 | CELL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 13 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | 6446R-3 |