RRC ID 47429
著者 Yoo SK, Pascoe HG, Pereira T, Kondo S, Jacinto A, Zhang X, Hariharan IK.
タイトル Plexins function in epithelial repair in both Drosophila and zebrafish.
ジャーナル Nat Commun
Abstract In most multicellular organisms, homeostasis is contingent upon maintaining epithelial integrity. When unanticipated insults breach epithelial barriers, dormant programmes of tissue repair are immediately activated. However, many of the mechanisms that repair damaged epithelia remain poorly characterized. Here we describe a role for Plexin A (PlexA), a protein with particularly well-characterized roles in axonal pathfinding, in the healing of damaged epithelia in Drosophila. Semaphorins, which are PlexA ligands, also regulate tissue repair. We show that Drosophila PlexA has GAP activity for the Rap1 GTPase, which is known to regulate the stability of adherens junctions. Our observations suggest that the inhibition of Rap1 activity by PlexA in damaged Drosophila epithelia allows epithelial remodelling, thus facilitating wound repair. We also demonstrate a role for Plexin A1, a zebrafish orthologue of Drosophila PlexA, in epithelial repair in zebrafish tail fins. Thus, plexins function in epithelial wound healing in diverse taxa.
巻・号 7
ページ 12282
公開日 2016-7-25
DOI 10.1038/ncomms12282
PII ncomms12282
PMID 27452696
PMC PMC4962468
MeSH Actins / metabolism Adherens Junctions / metabolism Animal Fins / metabolism Animals Cell Adhesion Molecules / metabolism* Drosophila melanogaster / metabolism* Epithelial Cells / metabolism Epithelium / metabolism* Nerve Tissue Proteins / metabolism* RNA Interference Signal Transduction Wound Healing* Zebrafish / metabolism*
IF 12.121
引用数 14
WOS 分野 CELL BIOLOGY
リソース情報
ショウジョウバエ 6446R-3