論文 - 詳細
| RRC ID | 47458 |
|---|---|
| 著者 | Kishimoto W, Nishikori M, Arima H, Miyoshi H, Sasaki Y, Kitawaki T, Shirakawa K, Kato T, Imaizumi Y, Ishikawa T, Ohno H, Haga H, Ohshima K, Takaori-Kondo A. |
| タイトル | Expression of Tim-1 in primary CNS lymphoma. |
| ジャーナル | Cancer Med |
| Abstract |
Primary central nervous system lymphoma (PCNSL) is a distinct subtype of extranodal lymphoma with aggressive clinical course and poor outcome. As increased IL-10/IL-6 ratio is recognized in the cerebrospinal fluid (CSF) of PCNSL patients, we hypothesized that PCNSL might originate from a population of B cells with high IL-10-producing capacity, an equivalent of "regulatory B cells" in mice. We intended in this study to clarify whether Tim-1, a molecule known as a marker for regulatory B cells in mice, is expressed in PCNSL. By immunohistochemical analysis, Tim-1 was shown to be positive in as high as 54.2% of PCNSL (26 of 58 samples), while it was positive in 19.1% of systemic diffuse large B-cell lymphoma (DLBCL) samples (17 of 89 samples; P < 0.001). Tim-1 expression positively correlated with IL-10 expression in PCNSL (Cramer's V = 0.55, P < 0.001), and forced expression of Tim-1 in a PCNSL cell line resulted in increased IL-10 secretion, suggesting that Tim-1 is functionally linked with IL-10 production in PCNSL. Moreover, soluble Tim-1 was detectable in the CSF of PCNSL patients, and was suggested to parallel disease activity. In summary, PCNSL is characterized by frequent Tim-1 expression, and its soluble form in CSF may become a useful biomarker for PCNSL. |
| 巻・号 | 5(11) |
| ページ | 3235-3245 |
| 公開日 | 2016-11-1 |
| DOI | 10.1002/cam4.930 |
| PMID | 27709813 |
| PMC | PMC5119979 |
| MeSH | Animals B-Lymphocytes / metabolism B-Lymphocytes / pathology Biomarkers, Tumor Cell Line, Tumor Central Nervous System Neoplasms / genetics* Central Nervous System Neoplasms / metabolism Central Nervous System Neoplasms / pathology Databases, Genetic Female Gene Expression* Hepatitis A Virus Cellular Receptor 1 / genetics* Hepatitis A Virus Cellular Receptor 1 / metabolism Humans Immunohistochemistry Interleukin-10 / metabolism Interleukin-6 / metabolism Lymphoma / genetics* Lymphoma / metabolism Lymphoma / pathology Male Mice T-Lymphocytes / immunology T-Lymphocytes / metabolism |
| IF | 3.491 |
| 引用数 | 6 |
| WOS 分野 | ONCOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 各媒体での言及数の合計 | 0 |
| リソース情報 | |
| 遺伝子材料 | CS-CA-GFP (RDB05964) pCAG-HIVgp (RDB04394) pCMV-VSV-G-RSV-Rev (RDB04393). |