論文 - 詳細
| RRC ID | 47493 |
|---|---|
| 著者 | Murata W, Kinpara S, Kitahara N, Yamaguchi Y, Ogita A, Tanaka T, Fujita K. |
| タイトル | Cytoskeletal impairment during isoamyl alcohol-induced cell elongation in budding yeast. |
| ジャーナル | Sci Rep |
| Abstract |
Isoamyl alcohol (IAA) induces pseudohyphae including cell elongation in the budding yeast Saccharomyces cerevisiae. Detailed regulation of microtubules and actin in developmental transition during cell elongation is poorly understood. Here, we show that although IAA did not affect the intracellular actin level, it reduced the levels of both α- and β-tubulins. In budding yeast, cytoplasmic microtubules are linked to actin via complexes consisting of at least Kar9, Bim1, and Myo2, and reach from the spindle pole body to the cortical attachment site at the bud tip. However, IAA did not affect migration of Myo2 to the bud tip and kept Kar9 in the interior portion of the cell. In addition, bud elongation was observed in Kar9-overexpressing cells in the absence of IAA. These results indicate that impairment of the link between cytoplasmic microtubules and actin is possibly involved in the lowered interaction of Myo2 with Kar9. Our study might explain the reason for delayed cell cycle during IAA-induced cell elongation. |
| 巻・号 | 6 |
| ページ | 31127 |
| 公開日 | 2016-8-10 |
| DOI | 10.1038/srep31127 |
| PII | srep31127 |
| PMID | 27507042 |
| PMC | PMC4979020 |
| MeSH | Cytoskeleton / metabolism* Pentanols / metabolism* Saccharomyces cerevisiae / cytology Saccharomyces cerevisiae / metabolism* Tubulin / metabolism |
| IF | 3.998 |
| 引用数 | 0 |
| WOS 分野 | CELL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 酵母 | BY23323 BY24051 |