Reference - Detail
| RRC ID | 47504 |
|---|---|
| Author | Tran CM, Tanaka K, Yamagishi Y, Goto T, Mikamo H, Watanabe K. |
| Title | In vitro antimicrobial activity of razupenem (SMP-601, PTZ601) against anaerobic bacteria. |
| Journal | Antimicrob Agents Chemother |
| Abstract |
We evaluated the in vitro antianaerobic activity of razupenem (SMP-601, PTZ601), a new parenterally administered carbapenem, against 70 reference strains and 323 clinical isolates. Razupenem exhibited broad-spectrum activity against anaerobes, inhibiting most of the reference strains when used at a concentration of ≤1 μg/ml. Furthermore, it exhibited strong activity, comparable to those of other carbapenems (meropenem and doripenem), against clinically isolated non-fragilis Bacteroides spp. (MIC90s of 2 μg/ml), with MIC90 values of 0.06, 0.03, and 0.5 μg/ml against Prevotella spp., Porphyromonas spp., and Fusobacterium spp., respectively. Clinical isolates of anaerobic Gram-positive cocci, Eggerthella spp., and Clostridium spp. were highly susceptible to razupenem (MIC90s, 0.03 to 1 μg/ml). |
| Volume | 55(5) |
| Pages | 2398-402 |
| Published | 2011-5-1 |
| DOI | 10.1128/AAC.01038-10 |
| PII | AAC.01038-10 |
| PMID | 21343447 |
| PMC | PMC3088197 |
| MeSH | Bacteria, Anaerobic / drug effects* Carbapenems / pharmacology* Fusobacterium / drug effects Gram-Negative Anaerobic Bacteria / drug effects Gram-Positive Bacteria / drug effects Microbial Sensitivity Tests Porphyromonas / drug effects Prevotella / drug effects |
| IF | 4.904 |
| Times Cited | 9 |
| WOS Category | PHARMACOLOGY & PHARMACY MICROBIOLOGY |
| Resource | |
| General Microbes | JCM 1255 JCM 1132 JCM 1059 JCM 1134 JCM 1173 JCM 1149 JCM 1112 JCM 1231 JCM 8538 JCM 6325 |