RRC ID 47561
Author Khatuntseva EA, Men'shov VM, Shashkov AS, Tsvetkov YE, Stepanenko RN, Vlasenko RY, Shults EE, Tolstikov GA, Tolstikova TG, Baev DS, Kaledin VA, Popova NA, Nikolin VP, Laktionov PP, Cherepanova AV, Kulakovskaya TV, Kulakovskaya EV, Nifantiev NE.
Title Triterpenoid saponins from the roots of Acanthophyllum gypsophiloides Regel.
Journal Beilstein J Org Chem
Abstract Two new triterpenoid saponins 1 and 2 were isolated from the methanol extract of the roots of Acanthophyllum gypsophiloides Regel. These saponins have quillaic acid or gypsogenin moieties as an aglycon, and both bear similar sets of two oligosaccharide chains, which are 3-O-linked to the triterpenoid part trisaccharide α-L-Arap-(1→3)-[α-D-Galp-(1→2)]-β-D-GlcpA and pentasaccharide β-D-Xylp-(1→3)-β-D-Xylp-(1→3)-α-L-Rhap-(1→2)-[β-D-Quip-(1→4)]-β-D-Fucp connected through an ester linkage to C-28. The structures of the obtained saponins were elucidated by a combination of mass spectrometry and 2D NMR spectroscopy. A study of acute toxicity, hemolytic, anti-inflammatory, immunoadjuvant and antifungal activity was carried out. Both saponins 1 and 2 were shown to exhibit immunoadjuvant properties within the vaccine composition with keyhole limpet hemocyanin-based immunogen. The availability of saponins 1 and 2 as individual pure compounds from the extract of the roots of A. gypsophiloides makes it a prospective source of immunoactive agents.
Volume 8
Pages 763-75
Published 2012-1-1
DOI 10.3762/bjoc.8.87
Description http://www.beilstein-journals.org/bjoc/single/articleFullText.htm?publicId=1860-5397-8-87
PMID 23015825
PMC PMC3388865
IF 2.622
Times Cited 8
WOS Category CHEMISTRY, ORGANIC
Resource
General Microbes JCM 1542