論文 - 詳細
| RRC ID | 47561 |
|---|---|
| 著者 | Khatuntseva EA, Men'shov VM, Shashkov AS, Tsvetkov YE, Stepanenko RN, Vlasenko RY, Shults EE, Tolstikov GA, Tolstikova TG, Baev DS, Kaledin VA, Popova NA, Nikolin VP, Laktionov PP, Cherepanova AV, Kulakovskaya TV, Kulakovskaya EV, Nifantiev NE. |
| タイトル | Triterpenoid saponins from the roots of Acanthophyllum gypsophiloides Regel. |
| ジャーナル | Beilstein J Org Chem |
| Abstract |
Two new triterpenoid saponins 1 and 2 were isolated from the methanol extract of the roots of Acanthophyllum gypsophiloides Regel. These saponins have quillaic acid or gypsogenin moieties as an aglycon, and both bear similar sets of two oligosaccharide chains, which are 3-O-linked to the triterpenoid part trisaccharide α-L-Arap-(1→3)-[α-D-Galp-(1→2)]-β-D-GlcpA and pentasaccharide β-D-Xylp-(1→3)-β-D-Xylp-(1→3)-α-L-Rhap-(1→2)-[β-D-Quip-(1→4)]-β-D-Fucp connected through an ester linkage to C-28. The structures of the obtained saponins were elucidated by a combination of mass spectrometry and 2D NMR spectroscopy. A study of acute toxicity, hemolytic, anti-inflammatory, immunoadjuvant and antifungal activity was carried out. Both saponins 1 and 2 were shown to exhibit immunoadjuvant properties within the vaccine composition with keyhole limpet hemocyanin-based immunogen. The availability of saponins 1 and 2 as individual pure compounds from the extract of the roots of A. gypsophiloides makes it a prospective source of immunoactive agents. |
| 巻・号 | 8 |
| ページ | 763-75 |
| 公開日 | 2012-1-1 |
| DOI | 10.3762/bjoc.8.87 |
| 解説 | http://www.beilstein-journals.org/bjoc/single/articleFullText.htm?publicId=1860-5397-8-87 |
| PMID | 23015825 |
| PMC | PMC3388865 |
| IF | 2.622 |
| 引用数 | 8 |
| WOS 分野 | CHEMISTRY, ORGANIC |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 一般微生物 | JCM 1542 |