論文 - 詳細
| RRC ID | 47569 |
|---|---|
| 著者 | Noguchi S, Hattori M, Sugiyama H, Hanaoka A, Okada S, Yoshida T. |
| タイトル | Lactobacillus plantarum NRIC1832 enhances IL-10 production from CD4⁺ T cells in vitro. |
| ジャーナル | Biosci Biotechnol Biochem |
| Abstract |
The anti-inflammatory effect of lactic acid bacteria (LAB) has been reported in several models for autoimmune diseases. It was considered in those studies that IL-10 induced by LAB might have been involved in such anti-inflammatory activity. We therefore examined the IL-10-inducing activity of LAB in detail by using an in vitro culture system of DO11.10 splenocytes. Most strains of LAB tested in this study increased IL-10 production. A further study using one of the tested strains with potent immune-regulatory activity, Lactobacillus plantarum NRIC1832, showed that the enhanced IL-10 was mainly produced by T cells. However, this enhancement required several types of cells other than T cells. NRIC1832 enhanced IL-10 production after short-term exposure to T cells, but this effect diminished after long-term exposure, indicating that the enhancement of IL-10 production by NRIC1832 was temporary, in contrast to the enhancement of IFN-γ production which was still apparent after long-term exposure. |
| 巻・号 | 76(10) |
| ページ | 1925-31 |
| 公開日 | 2012-1-1 |
| DOI | 10.1271/bbb.120404 |
| PII | DN/JST.JSTAGE/bbb/120404 |
| 解説 | http://www.tandfonline.com/doi/pdf/10.1271/bbb.120404 |
| PMID | 23047110 |
| MeSH | Animals CD4-Positive T-Lymphocytes / cytology CD4-Positive T-Lymphocytes / immunology CD4-Positive T-Lymphocytes / metabolism* CD4-Positive T-Lymphocytes / microbiology* Cell Differentiation Interferon-gamma / biosynthesis Interleukin-10 / biosynthesis* Lactobacillus plantarum / physiology* Mice Mice, Inbred BALB C Mice, Transgenic Spleen / cytology |
| IF | 1.516 |
| 引用数 | 9 |
| WOS 分野 | FOOD SCIENCE & TECHNOLOGY BIOTECHNOLOGY & APPLIED MICROBIOLOGY CHEMISTRY, APPLIED BIOCHEMISTRY & MOLECULAR BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 各媒体での言及数の合計 | 0 |
| リソース情報 | |
| 一般微生物 | JCM 1149 JCM 1173 JCM 1150 JCM 1231 JCM 1062 JCM 1248 JCM 1157 JCM 1022 JCM 5813 |