RRC ID 47569
Author Noguchi S, Hattori M, Sugiyama H, Hanaoka A, Okada S, Yoshida T.
Title Lactobacillus plantarum NRIC1832 enhances IL-10 production from CD4⁺ T cells in vitro.
Journal Biosci. Biotechnol. Biochem.
Abstract The anti-inflammatory effect of lactic acid bacteria (LAB) has been reported in several models for autoimmune diseases. It was considered in those studies that IL-10 induced by LAB might have been involved in such anti-inflammatory activity. We therefore examined the IL-10-inducing activity of LAB in detail by using an in vitro culture system of DO11.10 splenocytes. Most strains of LAB tested in this study increased IL-10 production. A further study using one of the tested strains with potent immune-regulatory activity, Lactobacillus plantarum NRIC1832, showed that the enhanced IL-10 was mainly produced by T cells. However, this enhancement required several types of cells other than T cells. NRIC1832 enhanced IL-10 production after short-term exposure to T cells, but this effect diminished after long-term exposure, indicating that the enhancement of IL-10 production by NRIC1832 was temporary, in contrast to the enhancement of IFN-γ production which was still apparent after long-term exposure.
Volume 76(10)
Pages 1925-31
Published 2012
DOI 10.1271/bbb.120404
PII DN/JST.JSTAGE/bbb/120404
Description http://www.tandfonline.com/doi/pdf/10.1271/bbb.120404
PMID 23047110
MeSH Animals CD4-Positive T-Lymphocytes / cytology CD4-Positive T-Lymphocytes / immunology CD4-Positive T-Lymphocytes / metabolism* CD4-Positive T-Lymphocytes / microbiology* Cell Differentiation Interferon-gamma / biosynthesis Interleukin-10 / biosynthesis* Lactobacillus plantarum / physiology* Mice Mice, Inbred BALB C Mice, Transgenic Spleen / cytology
IF 1.255
Times Cited 2
WOS Category FOOD SCIENCE & TECHNOLOGY BIOTECHNOLOGY & APPLIED MICROBIOLOGY CHEMISTRY, APPLIED BIOCHEMISTRY & MOLECULAR BIOLOGY
Resource
General Microbes JCM 1149 JCM 1173 JCM 1150 JCM 1231 JCM 1062 JCM 1248 JCM 1157 JCM 1022 JCM 5813