RRC ID |
47569
|
著者 |
Noguchi S, Hattori M, Sugiyama H, Hanaoka A, Okada S, Yoshida T.
|
タイトル |
Lactobacillus plantarum NRIC1832 enhances IL-10 production from CD4⁺ T cells in vitro.
|
ジャーナル |
Biosci Biotechnol Biochem
|
Abstract |
The anti-inflammatory effect of lactic acid bacteria (LAB) has been reported in several models for autoimmune diseases. It was considered in those studies that IL-10 induced by LAB might have been involved in such anti-inflammatory activity. We therefore examined the IL-10-inducing activity of LAB in detail by using an in vitro culture system of DO11.10 splenocytes. Most strains of LAB tested in this study increased IL-10 production. A further study using one of the tested strains with potent immune-regulatory activity, Lactobacillus plantarum NRIC1832, showed that the enhanced IL-10 was mainly produced by T cells. However, this enhancement required several types of cells other than T cells. NRIC1832 enhanced IL-10 production after short-term exposure to T cells, but this effect diminished after long-term exposure, indicating that the enhancement of IL-10 production by NRIC1832 was temporary, in contrast to the enhancement of IFN-γ production which was still apparent after long-term exposure.
|
巻・号 |
76(10)
|
ページ |
1925-31
|
公開日 |
2012-1-1
|
DOI |
10.1271/bbb.120404
|
PII |
DN/JST.JSTAGE/bbb/120404
|
解説 |
http://www.tandfonline.com/doi/pdf/10.1271/bbb.120404
|
PMID |
23047110
|
MeSH |
Animals
CD4-Positive T-Lymphocytes / cytology
CD4-Positive T-Lymphocytes / immunology
CD4-Positive T-Lymphocytes / metabolism*
CD4-Positive T-Lymphocytes / microbiology*
Cell Differentiation
Interferon-gamma / biosynthesis
Interleukin-10 / biosynthesis*
Lactobacillus plantarum / physiology*
Mice
Mice, Inbred BALB C
Mice, Transgenic
Spleen / cytology
|
IF |
1.516
|
引用数 |
9
|
WOS 分野
|
FOOD SCIENCE & TECHNOLOGY
BIOTECHNOLOGY & APPLIED MICROBIOLOGY
CHEMISTRY, APPLIED
BIOCHEMISTRY & MOLECULAR BIOLOGY
|
リソース情報 |
一般微生物 |
JCM 1149
JCM 1173
JCM 1150
JCM 1231
JCM 1062
JCM 1248
JCM 1157
JCM 1022
JCM 5813 |