論文 - 詳細
| RRC ID | 47579 |
|---|---|
| 著者 | Iwabuchi N, Yonezawa S, Odamaki T, Yaeshima T, Iwatsuki K, Xiao JZ. |
| タイトル | Immunomodulating and anti-infective effects of a novel strain of Lactobacillus paracasei that strongly induces interleukin-12. |
| ジャーナル | FEMS Immunol Med Microbiol |
| Abstract |
Several studies have demonstrated that some strains of lactic acid bacteria (LAB) can elicit natural killer (NK) cell activities via interleukin-12 (IL-12) induction and protect against influenza virus (IFV) infection. LAB strains that strongly induce IL-12 are expected to be effective in protecting against IFV infection. In this study, we screened 85 strains for their ability to induce the in vitro production of IL-12, and Lactobacillus paracasei MoLac-1 most strongly induced IL-12. To examine the immunomodulating effects of MoLac-1, we have performed in vitro studies using murine splenocytes. Heat-killed MoLac-1 cells induced IL-12 and interferon-γ (IFN-γ) production by murine splenocytes. Experiments using splenocytes depleted of various cell populations indicated that macrophages might be a major source of MoLac-1-induced IL-12 secretion. Intracellular staining of IFN-γ suggested that MoLac-1 activated NK cells and induced IFN-γ production by NK cells in vitro. Oral administration of heat-killed MoLac-1 increased the proportion of NK cells in spleen, and ameliorated the symptoms of IFV infection in mice. These results suggest that heat-killed MoLac-1 has the potential to modulate innate immunity and is useful for alleviation of the symptoms of IFV infection. |
| 巻・号 | 66(2) |
| ページ | 230-9 |
| 公開日 | 2012-11-1 |
| DOI | 10.1111/j.1574-695X.2012.01003.x |
| PMID | 22775119 |
| MeSH | Animals Disease Models, Animal Interferon-gamma / metabolism Interleukin-12 / metabolism* Killer Cells, Natural / immunology Killer Cells, Natural / microbiology Lactobacillus / immunology* Leukocytes, Mononuclear / immunology* Leukocytes, Mononuclear / microbiology* Macrophages / immunology Macrophages / microbiology Mice Mice, Inbred BALB C Orthomyxoviridae / immunology Orthomyxoviridae Infections / pathology Orthomyxoviridae Infections / therapy Spleen / immunology |
| 引用数 | 11 |
| WOS 分野 | INFECTIOUS DISEASES MICROBIOLOGY IMMUNOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 6 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 一般微生物 | JCM 8713 |