論文 - 詳細
| RRC ID | 47675 |
|---|---|
| 著者 | Kuwahara M, Ise W, Ochi M, Suzuki J, Kometani K, Maruyama S, Izumoto M, Matsumoto A, Takemori N, Takemori A, Shinoda K, Nakayama T, Ohara O, Yasukawa M, Sawasaki T, Kurosaki T, Yamashita M. |
| タイトル | Bach2-Batf interactions control Th2-type immune response by regulating the IL-4 amplification loop. |
| ジャーナル | Nat Commun |
| Abstract |
Although Bach2 has an important role in regulating the Th2-type immune response, the underlying molecular mechanisms remain unclear. We herein demonstrate that Bach2 associates with Batf and binds to the regulatory regions of the Th2 cytokine gene loci. The Bach2-Batf complex antagonizes the recruitment of the Batf-Irf4 complex to AP-1 motifs and suppresses Th2 cytokine production. Furthermore, we find that Bach2 regulates the Batf and Batf3 expressions via two distinct pathways. First, Bach2 suppresses the maintenance of the Batf and Batf3 expression through the inhibition of IL-4 production. Second, the Bach2-Batf complex directly binds to the Batf and Batf3 gene loci and reduces transcription by interfering with the Batf-Irf4 complex. These findings suggest that IL-4 and Batf form a positive feedback amplification loop to induce Th2 cell differentiation and the subsequent Th2-type immune response, and Bach2-Batf interactions are required to prevent an excessive Th2 response. |
| 巻・号 | 7 |
| ページ | 12596 |
| 公開日 | 2016-9-1 |
| DOI | 10.1038/ncomms12596 |
| PII | ncomms12596 |
| PMID | 27581382 |
| PMC | PMC5025763 |
| MeSH | Animals Basic-Leucine Zipper Transcription Factors / genetics* Basic-Leucine Zipper Transcription Factors / metabolism* Cell Differentiation / immunology Female Gene Expression Regulation Interferon Regulatory Factors / genetics* Interferon Regulatory Factors / metabolism Interleukin-4 / biosynthesis Interleukin-4 / immunology Male Mice Mice, Inbred C57BL Mice, Knockout Repressor Proteins / genetics* Repressor Proteins / metabolism STAT6 Transcription Factor / genetics Th2 Cells / immunology* Transcription, Genetic / genetics |
| IF | 12.121 |
| 引用数 | 31 |
| WOS 分野 | IMMUNOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 遺伝子材料 | pCMV-HA-Bach2 wt (RDB14569) pCMV-HA-Bach2 L687A (RDB14570) pCMV-HA-Bach2 L694A (RDB14571) pCMV-Myc-Batf (RDB14572). |