論文 - 詳細
| RRC ID | 47916 |
|---|---|
| 著者 | Lai CM, Lin KY, Kao SH, Chen YN, Huang F, Hsu HJ. |
| タイトル | Hedgehog signaling establishes precursors for germline stem cell niches by regulating cell adhesion. |
| ジャーナル | J Cell Biol |
| Abstract |
Stem cells require different types of supporting cells, or niches, to control stem cell maintenance and differentiation. However, little is known about how those niches are formed. We report that in the development of the Drosophila melanogaster ovary, the Hedgehog (Hh) gradient sets differential cell affinity for somatic gonadal precursors to specify stromal intermingled cells, which contributes to both germline stem cell maintenance and differentiation niches in the adult. We also report that Traffic Jam (an orthologue of a large Maf transcription factor in mammals) is a novel transcriptional target of Hh signaling to control cell-cell adhesion by negative regulation of E-cadherin expression. Our results demonstrate the role of Hh signaling in niche establishment by segregating somatic cell lineages for differentiation. |
| 巻・号 | 216(5) |
| ページ | 1439-1453 |
| 公開日 | 2017-5-1 |
| DOI | 10.1083/jcb.201610063 |
| PII | jcb.201610063 |
| PMID | 28363970 |
| PMC | PMC5412570 |
| MeSH | Animals Cell Adhesion* Drosophila melanogaster Female Germ Cells / metabolism* Hedgehog Proteins / metabolism* Ovary / cytology Ovary / metabolism Signal Transduction* Stem Cell Niche* |
| IF | 8.811 |
| 引用数 | 11 |
| WOS 分野 | CELL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 20 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | 11561R-1 2411R-1 2125R-1 |