| RRC ID |
4794
|
| 著者 |
Onuma Y, Haramoto Y, Nejigane S, Takahashi S, Asashima M.
|
| タイトル |
Bestrophin genes are expressed in Xenopus development.
|
| ジャーナル |
Biochem Biophys Res Commun
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| Abstract |
The Bestrophin-1/VMD2 gene has been implicated in Best disease, a juvenile-onset vitelliform macular dystrophy. The Bestrophin proteins have anion channel activity, and the four mammalian members share sequence homologies in multiple transmembrane domains and an RFP-tripeptide motif. The expression patterns and functions of the Bestrophin genes in retinal pigment epithelium have been studied intensively, whereas little is known about their roles in vertebrate embryogenesis. This study examined the roles of four Xenopus tropicalis homologs of BEST genes. The xtBest genes showed spatially and temporally distinct expression. xtBest-2 was the only maternally expressed Best gene, and both xtBest-2 and the Xenopus laevis Best-2 gene were expressed at the edge of the blastopore lip including the organizer. Ectopic expression of xBest-2 caused defects in dorsal axis formation and in mesodermal gene expression during gastrulation. These results suggest a new role of the Bestrophin family genes in early vertebrate embryogenesis.
|
| 巻・号 |
384(3)
|
| ページ |
290-5
|
| 公開日 |
2009-7-3
|
| DOI |
10.1016/j.bbrc.2009.04.117
|
| PII |
S0006-291X(09)00821-3
|
| PMID |
19406105
|
| MeSH |
Amino Acid Sequence
Animals
Chloride Channels / genetics*
Gene Expression
Gene Expression Regulation, Developmental*
Molecular Sequence Data
Xenopus / embryology*
Xenopus / genetics
|
| IF |
2.985
|
| 引用数 |
2
|
|
WOS 分野
|
BIOPHYSICS
BIOCHEMISTRY & MOLECULAR BIOLOGY
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| リソース情報 |
| ツメガエル・イモリ |
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