論文 - 詳細
| RRC ID | 47949 |
|---|---|
| 著者 | Schwarz J, Bringmann H. |
| タイトル | Analysis of the NK2 homeobox gene ceh-24 reveals sublateral motor neuron control of left-right turning during sleep. |
| ジャーナル | Elife |
| Abstract |
Sleep is a behavior that is found in all animals that have a nervous system and that have been studied carefully. In Caenorhabditis elegans larvae, sleep is associated with a turning behavior, called flipping, in which animals rotate 180° about their longitudinal axis. However, the molecular and neural substrates of this enigmatic behavior are not known. Here, we identified the conserved NK-2 homeobox gene ceh-24 to be crucially required for flipping. ceh-24 is required for the formation of processes and for cholinergic function of sublateral motor neurons, which separately innervate the four body muscle quadrants. Knockdown of cholinergic function in a subset of these sublateral neurons, the SIAs, abolishes flipping. The SIAs depolarize during flipping and their optogenetic activation induces flipping in a fraction of events. Thus, we identified the sublateral SIA neurons to control the three-dimensional movements of flipping. These neurons may also control other types of motion. |
| 巻・号 | 6 |
| 公開日 | 2017-2-28 |
| DOI | 10.7554/eLife.24846 |
| PII | e24846 |
| PMID | 28244369 |
| PMC | PMC5384828 |
| MeSH | Animals Caenorhabditis elegans / physiology* Caenorhabditis elegans Proteins / metabolism* Homeodomain Proteins / metabolism* Larva / physiology Motor Activity* Motor Neurons / physiology* Sleep* |
| IF | 7.08 |
| 引用数 | 3 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm1103 Phenotypes tested: sleeping during lethargus: normal flipping during lethargus: strongly reduced The 10x backcrossed version of the allele has been deposited at the cgc. |