| RRC ID |
48004
|
| Author |
Sugano Y, Kokusho R, Ueda M, Fujimoto M, Tsutsumi N, Shimada T, Kiuchi T, Katsuma S.
|
| Title |
Identification of a bipartite nuclear localization signal in the silkworm Masc protein.
|
| Journal |
FEBS Lett
|
| Abstract |
The silkworm Masculinizer (Masc) gene encodes a CCCH-tandem zinc finger protein that controls both masculinization and dosage compensation. Masc protein is a nuclear protein, but the mechanism underlying the transport of this protein into the nucleus has not yet been elucidated. Here, we identified a functional bipartite nuclear localization signal (NLS) located between residues 274 and 290 of the Masc protein. Sequence comparison revealed that this bipartite NLS is evolutionarily conserved in Masc proteins from other lepidopteran insects. Furthermore, we showed that the degree of nuclear localization is not associated with the masculinizing activity of the Masc protein.
|
| Volume |
590(14)
|
| Pages |
2256-61
|
| Published |
2016-7-1
|
| DOI |
10.1002/1873-3468.12246
|
| PMID |
27277067
|
| MeSH |
Active Transport, Cell Nucleus / physiology
Animals
Bombyx / genetics
Bombyx / metabolism*
Cell Nucleus / genetics
Cell Nucleus / metabolism*
Insect Proteins / genetics
Insect Proteins / metabolism*
Nuclear Localization Signals / genetics
Nuclear Localization Signals / metabolism*
Nuclear Proteins / genetics
Nuclear Proteins / metabolism*
|
| IF |
3.057
|
| Times Cited |
4
|
|
WOS Category
|
BIOCHEMISTRY & MOLECULAR BIOLOGY
BIOPHYSICS
CELL BIOLOGY
|
| Resource |
| Silkworms |
|
