Reference - Detail
RRC ID | 48102 |
---|---|
Author | Takumi T, Ohkubo H, Nakanishi S. |
Title | Cloning of a membrane protein that induces a slow voltage-gated potassium current. |
Journal | Science |
Abstract |
A rat kidney messenger RNA that induces a slowly activating, voltage-dependent potassium current on its expression in Xenopus oocytes was identified by combining molecular cloning with an electrophysiological assay. The cloned complementary DNA encodes a novel membrane protein that consists of 130 amino acids with a single putative transmembrane domain. This protein differs from the known ion channel proteins but is involved in the induction of selective permeation of potassium ions by membrane depolarization. |
Volume | 242(4881) |
Pages | 1042-5 |
Published | 1988-11-18 |
DOI | 10.1126/science.3194754 |
PMID | 3194754 |
MeSH | Amino Acid Sequence Animals Base Sequence Blotting, Northern Cloning, Molecular DNA / genetics Electric Conductivity Membrane Potentials Membrane Proteins / genetics* Molecular Sequence Data Molecular Weight Potassium Channels / physiology* Rats Xenopus laevis |
IF | 41.846 |
Times Cited | 458 |
WOS Category | BIOCHEMISTRY & MOLECULAR BIOLOGY |
Resource | |
DNA material | pKI 27 (RDB13187) |