論文 - 詳細
| RRC ID | 48187 |
|---|---|
| 著者 | Asama T, Kimura Y, Kono T, Tatefuji T, Hashimoto K, Benno Y. |
| タイトル | Effects of heat-killed Lactobacillus kunkeei YB38 on human intestinal environment and bowel movement: a pilot study. |
| ジャーナル | Benef Microbes |
| Abstract |
It is well known that lactic acid bacteria supplementation is beneficial for intestinal conditions such as microbiota; however, the effects of killed-lactic acid bacteria on intestinal conditions are largely unclear. This study aimed to evaluate the effect of heat-killed Lactobacillus kunkeei YB38 (YB38) at a dose of approximately 10 mg/day on human intestinal environment and bowel movement. This single-blind study enrolled 29 female subjects with a low defecation frequency who consumed heat-killed YB38 at four increasing dosage levels: 0 (placebo), 2, 10, and 50 mg. Each dose was consumed daily for two weeks, with a two-week baseline period preceding the dosing-period and a two-week washout period ending the study. Observed levels of Bacteroides fragilis group significantly decreased with intake of heat-killed YB38 at ≥10 mg/day compared with levels during placebo intake (P<0.01). Faecal pH significantly decreased with 10 and 50 mg/day intake (P<0.01 and 0.05, respectively). Acetic acid levels tended to increase in faeces at the 50 mg/day dose (P<0.1). Bowel movement tended to increase in all heat-killed YB38 intake periods (P<0.1). In conclusion, heat-killed YB38 altered human intestinal microbiota at doses of ≥10 mg/day and tended to increase bowel movement at ≥2 mg/day. This is the first study to show the intestinal microbiota-altering effect of L. kunkeei and to report the bowel movement-improving effect of heat-killed lactic acid bacteria. |
| 巻・号 | 7(3) |
| ページ | 337-44 |
| 公開日 | 2016-6-1 |
| DOI | 10.3920/BM2015.0132 |
| PMID | 26839076 |
| MeSH | Acetic Acid / analysis Adult Bacterial Load Bacteroides fragilis / isolation & purification Feces / chemistry Feces / microbiology Female Gastrointestinal Microbiome / drug effects* Gastrointestinal Motility / drug effects* Humans Hydrogen-Ion Concentration Intestines / microbiology* Intestines / physiology* Lactobacillus* Middle Aged Pilot Projects Placebos / administration & dosage Probiotics / administration & dosage* Single-Blind Method |
| IF | 3.37 |
| 引用数 | 11 |
| WOS 分野 | MICROBIOLOGY NUTRITION & DIETETICS |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 一般微生物 | JCM 1471 JCM 5826 JCM 10188 JCM 1649 JCM 1217 |