Reference - Detail
| RRC ID | 48215 |
|---|---|
| Author | Tamura T, Ozawa M, Tanaka N, Arai S, Mura K. |
| Title | Bacillus cereus Response to a Proanthocyanidin Trimer, a Transcriptional and Functional Analysis. |
| Journal | Curr Microbiol |
| Abstract |
Proanthocyanidins are abundant in peanut skin, and in this study, the antibacterial effects of a peanut skin extract (PSE) against food-borne bacteria were investigated to find its minimum inhibitory concentration. Food-borne gram-positive bacteria, and in particular Bacillus cereus, was more sensitive to PSE. In particular, the inhibitory activity of epicatechin-(4β → 6)-epicatechin-(2β → O→7, 4β → 8)-catechin (EEC), a proanthocyanidin trimer from peanut skin, against B. cereus was stronger than that of procyanidin A1, a proanthocyanidin dimer. DNA microarray analysis of B. cereus treated with EEC was carried out, with a finding that 597 genes were significantly up-regulated. Analysis of the up-regulated genes suggested that EEC disrupted the normal condition of the cell membrane and wall of B. cereus and alter its usual nutritional metabolism. Moreover, treatment of B. cereus with EEC inhibited glucose uptake, suggesting that EEC affects the cell-surface adsorption. |
| Volume | 73(1) |
| Pages | 115-23 |
| Published | 2016-7-1 |
| DOI | 10.1007/s00284-016-1032-x |
| PII | 10.1007/s00284-016-1032-x |
| PMID | 27061585 |
| PMC | PMC4899491 |
| MeSH | Anti-Bacterial Agents / chemistry Anti-Bacterial Agents / pharmacology* Arachis / chemistry* Bacillus cereus / drug effects* Bacillus cereus / genetics Bacillus cereus / metabolism Bacterial Proteins / genetics Bacterial Proteins / metabolism Gene Expression Regulation, Bacterial / drug effects Molecular Structure Plant Extracts / chemistry Plant Extracts / pharmacology* Proanthocyanidins / chemistry Proanthocyanidins / pharmacology* Transcription, Genetic / drug effects |
| IF | 1.746 |
| Times Cited | 6 |
| WOS Category | MICROBIOLOGY |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | Patent(IFI CLAIMS) |
| Total number of mentions | 1 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| General Microbes | JCM 3752 JCM 3725 JCM 7577 |