| RRC ID |
48270
|
| 著者 |
Shin R, Itoh Y, Kataoka M, Iino-Miura S, Miura R, Mizutani T, Fujisawa T.
|
| タイトル |
Anti-tumor activity of heat-killed Lactobacillus plantarum BF-LP284 on Meth-A tumor cells in BALB/c mice.
|
| ジャーナル |
Int J Food Sci Nutr
|
| Abstract |
Probiotics exert numerous effects on human well-being. Here, heat-killed Lactobacillus plantarum BF-LP284 (H-Lp) was isolated as a potent immuno-modulator among 15 strains of lactobacilli in terms of TNF-α induction ability in peritoneal macrophages. In vitro TNF-α and IFN-γ induction in Peyer's patch (PP) cells was higher when incubated with H-Lp than with live L. plantarum BF-LP284 (L-Lp). Suppression of syngeneic Meth-A tumors in a murine model by oral administration of H-Lp was also greater than that of L-Lp and of controls. H-Lp stimulated IFN-γ production in spleen cells, which displayed inhibited tumor growth in Winn assays when treated with H-Lp. Moreover, H-Lp increased the ratio of CD3(+ )cells among peripheral blood mononuclear cells in Meth-A tumor-bearing mice, suggesting an H-Lp-mediated anti-tumor mechanism whereby immune cells that are activated by H-Lp in PP and acquire anti-tumor activity in the spleen migrate to tumor sites through lymphocyte homing to inhibit tumor growth.
|
| 巻・号 |
67(6)
|
| ページ |
641-9
|
| 公開日 |
2016-9-1
|
| DOI |
10.1080/09637486.2016.1185771
|
| PMID |
27198983
|
| MeSH |
Animals
Antineoplastic Agents / therapeutic use*
Cell Line, Tumor
Disease Models, Animal
Female
Hot Temperature
Interferon-gamma / metabolism
Lactobacillus plantarum*
Leukocytes, Mononuclear / metabolism
Leukocytes, Mononuclear / microbiology
Macrophages, Peritoneal / microbiology
Male
Mice
Mice, Inbred BALB C
Mice, Inbred ICR
Neoplasms, Experimental / therapy*
Peyer's Patches / cytology
Peyer's Patches / metabolism
Peyer's Patches / microbiology
Probiotics*
Spleen / cytology
Spleen / metabolism
Spleen / microbiology
Tumor Necrosis Factor-alpha / metabolism
|
| IF |
3.483
|
| 引用数 |
7
|
|
WOS 分野
|
FOOD SCIENCE & TECHNOLOGY
NUTRITION & DIETETICS
|
| リソース情報 |
| 一般微生物 |
JCM 1055
JCM 1057
JCM 1149
JCM 1551
JCM 6651
JCM 8341
JCM 8342
JCM 8344 |
