論文 - 詳細
| RRC ID | 48430 |
|---|---|
| 著者 | Wada S, Sawa R, Ohba S, Hayashi C, Umekita M, Shibuya Y, Iijima K, Iwanami F, Igarashi M. |
| タイトル | Stability and Bioavailability of Lentztrehaloses A, B, and C as Replacements for Trehalose. |
| ジャーナル | J Agric Food Chem |
| Abstract |
Trehalose is widely used as a sweetener, humectant, and stabilizer, but is ubiquitously degraded by the enzyme trehalase expressed in a broad variety of organisms. The stability of the new trehalose analogues lentztrehaloses A, B, and C in microbial and mammalian cell cultures and their pharmacokinetics in mice were analyzed to evaluate their potential as successors of trehalose. Among the 12 species of microbes and 2 cancer cell lines tested, 7 digested trehalose, whereas no definitive digestion of the lentztrehaloses was observed in any of them. When orally administered to mice (0.5 g/kg), trehalose was not clearly detected in blood and urine and only slightly detected in feces. However, lentztrehaloses were detected in blood at >1 μg/mL over several hours and were eventually excreted in feces and urine. These results indicate that lentztrehaloses may potentially replace trehalose as nonperishable materials and drug candidates with better bioavailabilities. |
| 巻・号 | 64(38) |
| ページ | 7121-6 |
| 公開日 | 2016-9-28 |
| DOI | 10.1021/acs.jafc.6b02782 |
| PMID | 27595314 |
| MeSH | Animals Bacteroides fragilis / drug effects Bacteroides fragilis / metabolism Biological Availability Candida albicans / drug effects Candida albicans / growth & development Cell Line, Tumor Disease Models, Animal Enterococcus faecalis / drug effects Enterococcus faecalis / metabolism Feces / chemistry Female Humans Intestinal Mucosa / metabolism Intestines / cytology Intestines / drug effects Mice Mice, Inbred ICR Micrococcus luteus / drug effects Micrococcus luteus / growth & development Mycobacterium smegmatis / drug effects Mycobacterium smegmatis / metabolism Trehalose / analogs & derivatives* Trehalose / blood Trehalose / chemistry Trehalose / pharmacokinetics* Trehalose / urine |
| IF | 4.192 |
| 引用数 | 3 |
| WOS 分野 | AGRICULTURE, MULTIDISCIPLINARY FOOD SCIENCE & TECHNOLOGY CHEMISTRY, APPLIED |
| リソース情報 | |
| 一般微生物 | JCM 5803 JCM 11019 |