Reference - Detail
RRC ID | 48430 |
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Author | Wada S, Sawa R, Ohba S, Hayashi C, Umekita M, Shibuya Y, Iijima K, Iwanami F, Igarashi M. |
Title | Stability and Bioavailability of Lentztrehaloses A, B, and C as Replacements for Trehalose. |
Journal | J Agric Food Chem |
Abstract |
Trehalose is widely used as a sweetener, humectant, and stabilizer, but is ubiquitously degraded by the enzyme trehalase expressed in a broad variety of organisms. The stability of the new trehalose analogues lentztrehaloses A, B, and C in microbial and mammalian cell cultures and their pharmacokinetics in mice were analyzed to evaluate their potential as successors of trehalose. Among the 12 species of microbes and 2 cancer cell lines tested, 7 digested trehalose, whereas no definitive digestion of the lentztrehaloses was observed in any of them. When orally administered to mice (0.5 g/kg), trehalose was not clearly detected in blood and urine and only slightly detected in feces. However, lentztrehaloses were detected in blood at >1 μg/mL over several hours and were eventually excreted in feces and urine. These results indicate that lentztrehaloses may potentially replace trehalose as nonperishable materials and drug candidates with better bioavailabilities. |
Volume | 64(38) |
Pages | 7121-6 |
Published | 2016-9-28 |
DOI | 10.1021/acs.jafc.6b02782 |
PMID | 27595314 |
MeSH | Animals Bacteroides fragilis / drug effects Bacteroides fragilis / metabolism Biological Availability Candida albicans / drug effects Candida albicans / growth & development Cell Line, Tumor Disease Models, Animal Enterococcus faecalis / drug effects Enterococcus faecalis / metabolism Feces / chemistry Female Humans Intestinal Mucosa / metabolism Intestines / cytology Intestines / drug effects Mice Mice, Inbred ICR Micrococcus luteus / drug effects Micrococcus luteus / growth & development Mycobacterium smegmatis / drug effects Mycobacterium smegmatis / metabolism Trehalose / analogs & derivatives* Trehalose / blood Trehalose / chemistry Trehalose / pharmacokinetics* Trehalose / urine |
IF | 4.192 |
Times Cited | 3 |
WOS Category | AGRICULTURE, MULTIDISCIPLINARY FOOD SCIENCE & TECHNOLOGY CHEMISTRY, APPLIED |
Resource | |
General Microbes | JCM 5803 JCM 11019 |