| RRC ID |
48503
|
| 著者 |
Harata G, He F, Takahashi K, Hosono A, Miyazawa K, Yoda K, Hiramatsu M, Kaminogawa S.
|
| タイトル |
Human Lactobacillus Strains from the Intestine can Suppress IgE-Mediated Degranulation of Rat Basophilic Leukaemia (RBL-2H3) Cells.
|
| ジャーナル |
Microorganisms
|
| Abstract |
Mast cells play a critical role in immunoglobulin E (IgE)-mediated allergic diseases, and the degranulation of mast cells is important in the pathogenesis of these diseases. A disturbance of the intestinal microflora, especially of endogenous lactic acid bacteria, might be a contributing factor for IgE-mediated allergic diseases. Additional knowledge regarding the interaction of human intestinal Lactobacilli with mast cells is still necessary. Twenty-three strains of Lactobacilli, including commercial and reference strains and strains from the human intestine, were tested for their ability to regulate degranulation of cells from rat basophilic leukemia RBL-2H3 cells (RBL-2H3) in vitro based on a β-hexosaminidase release assay. Each of the tested Lactobacilli characteristically suppressed IgE-mediated degranulation of RBL-2H3 cells, and Lactobacillus GG showed the strongest inhibitory effect on the cells. Furthermore, the bacteria isolated from the human intestine significantly suppressed degranulation of RBL-2H3 cellsin comparison with the reference strains. These results suggest that Lactobacilli, particularly those from the human intestine, can affect the activation of mast cells in a strain-dependent manner. Further study should be conducted to analyse the understanding mechanism.
|
| 巻・号 |
4(4)
|
| 公開日 |
2016-10-27
|
| DOI |
10.3390/microorganisms4040040
|
| PII |
microorganisms4040040
|
| PMID |
27801804
|
| PMC |
PMC5192523
|
| IF |
4.152
|
| リソース情報 |
| 一般微生物 |
JCM 1059
JCM 1112
JCM 1131
JCM 1132
JCM 1134
JCM 1136
JCM 1149
JCM 1231
JCM 2012 |
