論文 - 詳細
| RRC ID | 48503 |
|---|---|
| 著者 | Harata G, He F, Takahashi K, Hosono A, Miyazawa K, Yoda K, Hiramatsu M, Kaminogawa S. |
| タイトル | Human Lactobacillus Strains from the Intestine can Suppress IgE-Mediated Degranulation of Rat Basophilic Leukaemia (RBL-2H3) Cells. |
| ジャーナル | Microorganisms |
| Abstract |
Mast cells play a critical role in immunoglobulin E (IgE)-mediated allergic diseases, and the degranulation of mast cells is important in the pathogenesis of these diseases. A disturbance of the intestinal microflora, especially of endogenous lactic acid bacteria, might be a contributing factor for IgE-mediated allergic diseases. Additional knowledge regarding the interaction of human intestinal Lactobacilli with mast cells is still necessary. Twenty-three strains of Lactobacilli, including commercial and reference strains and strains from the human intestine, were tested for their ability to regulate degranulation of cells from rat basophilic leukemia RBL-2H3 cells (RBL-2H3) in vitro based on a β-hexosaminidase release assay. Each of the tested Lactobacilli characteristically suppressed IgE-mediated degranulation of RBL-2H3 cells, and Lactobacillus GG showed the strongest inhibitory effect on the cells. Furthermore, the bacteria isolated from the human intestine significantly suppressed degranulation of RBL-2H3 cellsin comparison with the reference strains. These results suggest that Lactobacilli, particularly those from the human intestine, can affect the activation of mast cells in a strain-dependent manner. Further study should be conducted to analyse the understanding mechanism. |
| 巻・号 | 4(4) |
| 公開日 | 2016-10-27 |
| DOI | 10.3390/microorganisms4040040 |
| PII | microorganisms4040040 |
| PMID | 27801804 |
| PMC | PMC5192523 |
| IF | 4.152 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 一般微生物 | JCM 1059 JCM 1112 JCM 1131 JCM 1132 JCM 1134 JCM 1136 JCM 1149 JCM 1231 JCM 2012 |